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Effects of ultraviolet treatment and alendronate immersion on osteoblast-like cells and human gingival fibroblasts cultured on titanium surfaces

Authors
 Changjoo Jeon  ;  Kyung Chul Oh  ;  Kyu-Hyung Park  ;  Hong Seok Moon 
Citation
 Scientific Reports, Vol.9(1) : 2581, 2019 
Journal Title
 Scientific Reports 
Issue Date
2019
Abstract
In this study, we evaluated the effects of ultraviolet (UV) treatment and alendronate (ALN) immersion on the proliferation and differentiation of MG-63 osteoblast-like cells and human gingival fibroblasts (HGFs) cultured on titanium surfaces. MG-63 cells were used for sandblasted, large grit, and acid-etched (SLA) titanium surfaces, and HGFs were used for machined (MA) titanium surfaces. SLA and MA specimens were subdivided into four groups (n = 12) according to the combination of surface treatments (UV treatment and/or ALN immersion) applied. After culturing MG-63 cells and HGFs on titanium discs, cellular morphology, proliferation, and differentiation were evaluated. The results revealed that UV treatment of titanium surfaces did not alter the proliferation of MG-63 cells; however, HGF differentiation and adhesion were increased in response to UV treatment. In contrast, ALN immersion of titanium discs reduced MG-63 cell proliferation and changed HGFs into a more atrophic form. Simultaneous application of UV treatment and ALN immersion induced greater differentiation of MG-63 cells. Within the limitations of this cellular level study, simultaneous application of UV treatment and ALN immersion of titanium surfaces was shown to improve the osseointegration of titanium implants; in addition, UV treatment may be used to enhance mucosal sealing of titanium abutments.
Files in This Item:
T201902486.pdf Download
DOI
10.1038/s41598-019-39355-3
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Oh, Kyung Chul(오경철) ORCID logo https://orcid.org/0000-0003-4584-2597
Jeon, Changjoo(전창주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170957
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