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Beyond X-Chromosome Inactivation: The Oncogenic Facet of XIST in Human Cancers

Authors
 Hamadi Madhi  ;  Myoung Hee Kim 
Citation
 Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.25(2) : 113-122, 2019 
Journal Title
 Journal of Experimental & Biomedcal Science (대한의생명과학회지) 
ISSN
 1738-3226 
Issue Date
2019
Keywords
X chromosome inactivation ; XIST ; LncRNA ; CeRNA ; Human cancer ; miRNA
Abstract
Long-non coding RNAs (LncRNAs) constitute a wide and extremely diverse family of RNA transcripts that are greater than 200 base pairs in length and are not translated into proteins. X-inactive specific transcript (XIST) was the first long non-coding RNA to be discovered, back in 1991. Its function in X-chromosome inactivation has been extensively studied for three decades, though other functional roles of XIST that involve a variety of fascinating mechanisms remain to be elucidated. Here, we review the emerging oncogenic role of XIST in various human cancers.
Files in This Item:
T201902464.pdf Download
DOI
10.15616/BSL.2019.25.2.113
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170947
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