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Efficient Self-Assembled MicroRNA Delivery System Consisting of Cholesterol-Conjugated MicroRNA and PEGylated Polycationic Polymer for Tumor Treatment

Authors
 Byeonggeol Mun  ;  Eunji Jang  ;  Seungmin Han  ;  Hye Young Son  ;  Yuna Choi  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 ACS Applied Bio Materials, Vol.2(5) : 2219-2228, 2019 
Journal Title
 ACS Applied Bio Materials 
Issue Date
2019
Keywords
self-assembled miRNA delivery ; RNA interference ; cholesterol conjugation ; polycationic polymer ; cancer therapy
Abstract
MicroRNA (miR), a key molecule involved in endogenous RNA interference, is a promising therapeutic agent. In vivo delivery of miR, however, is a major factor limiting its application because its polyanionic nature and vulnerability to breakdown make delivery of miR to targeted lesions difficult. To overcome these challenges, we developed a self-assembled miR delivery system consisting of cholesterol-conjugated miR and polyethylene glycol-grafted polyethylene imine. Nanosized complexes of miR with polyethylene imine, which protected miR and its delivery into targeted lesions in vivo, were successfully synthesized by polyethylene glycol grafting. The hydrophobicity of cholesterol improved the structural stability of the complex, preventing the loss of miR. Here, we report the preparation of this self-assembled complex. We examined the delivery efficiency and validated the therapeutic efficacy of the complex. In conclusion, our miR delivery system shows considerable potential for effective in vivo delivery of miR.
Full Text
https://pubs.acs.org/doi/10.1021/acsabm.9b00186
DOI
10.1021/acsabm.9b00186
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170904
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