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Exposure to environmental pollutants and a marker of early kidney injury in the general population: Results of a nationally representative cross-sectional study based on the Korean National Environmental Health Survey (KoNEHS) 2012-2014

Authors
 Sinye Lim  ;  Jin-Ha Yoon 
Citation
 Science of the Total Environment, Vol.681 : 175-182, 2019 
Journal Title
 Science of the Total Environment 
ISSN
 0048-9697 
Issue Date
2019
MeSH
Adult ; Biomarkers/metabolism ; Environmental Exposure/analysis* ; Environmental Exposure/statistics & numerical data ; Environmental Pollutants/metabolism* ; Female ; Humans ; Kidney/metabolism* ; Male ; Republic of Korea ; Surveys and Questionnaires ; Young Adult
Keywords
Chronic kidney diseases ; Early kidney injury ; Endocrine disrupter ; Environmental pollutants ; Heavy metal
Abstract
Exposure to environmental pollutants may lead to early kidney injury, chronic kidney disease (CKD) and end-stage renal disease (ESRD). This study investigated the early renal effects associated with exposure to endocrine-disrupting chemicals (EDCs) and heavy metals using general Korean population data. We used data from the Second Korean National Environmental Health Survey (2012-2014). As exposure markers, the concentrations of EDCs, such as triclosan (TCS), bisphenol A (BPA) and phthalate metabolites (DEHP, MnBP and MBzP), and heavy metals, such as cadmium, lead and mercury were analyzed. As an early kidney injury marker, the urinary concentration of β2-microglobulin (β2M) was measured. Multiple linear regression was used to analyze the relationship between environmental pollutants and β2M. A total of 5489 people (male: 2538, female: 2951) aged 19 years and older were enrolled. The geometric mean (GM) concentration of β2M in the total population was 1.88 μg/g creatinine (95% confidence interval (CI) 1.85-1.91). The β2M concentrations were significantly higher in cases of female, old age, low income, and presence of a history of diabetes mellitus or hypertension. The GM concentrations of urinary TCS and cadmium were 1.16 μg/g creatinine (95% CI 1.11-1.21) and 0.57 μg/g creatinine (95% CI 0.57-0.59), respectively. TCS, DEHP, cadmium, lead, and mercury exposure was significantly positively related to urinary β2M in the multiple regression analysis. β2M levels increased significantly with increases in the cadmium, mercury, and lead levels (p for trend <0.0001). The higher the DEHP, MnBP, and TCS concentrations, the higher the β2M level (p for trend <0.01). Environmental pollutants exposure significantly increased urinary β2M levels in the general Korean population. To prevent the development of early kidney injury and CKD, it is important to reduce environmental pollutants exposure through regulatory measures, and cooperation between related bodies in both developing and developed countries.
Full Text
https://www.sciencedirect.com/science/article/pii/S0048969719316018
DOI
10.1016/j.scitotenv.2019.04.081
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Ha(윤진하) ORCID logo https://orcid.org/0000-0003-4198-2955
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170899
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