Botulinum Toxin Injection for Managing Sleep Bruxism

Abstract

Botulinum toxin (BoNT), a potent neurotoxin that reversibly blocks presynaptic acetylcholine release, has been applied successfully to treat severe sleep bruxism (SB). However, little work has been reviewed on the effectiveness of BoNT and its injection protocol such as drug dose and injection sites in masticatory muscles. Therefore, we reviewed recent studies on application of BoNT in SB patients.