Cited 14 times in
Prognostic impact of programmed cell death ligand 1 expression on long-term oncologic outcomes in colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.date.accessioned | 2019-09-20T07:24:48Z | - |
dc.date.available | 2019-09-20T07:24:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170877 | - |
dc.description.abstract | The present study evaluated the association between programmed cell death ligand-1 (PD-L1) expression and long-term oncologic outcomes in colorectal cancer (CRC). PD-L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. Patients were grouped according to PD-L1 expression, with 82 (46.9%) and 93 (53.1%) in the low and high PD-L1 expression groups, respectively. The overall survival (OS) and disease-free survival (DFS) rates were significantly better in the high expression group compared with in the low expression group (OS: 48.2 vs. 32.9%, P=0.047; DFS: 43.3 vs. 32.9%, P=0.021). According to the Tumor-Node-Metastasis stage subgroups, the OS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.789), 19.6 and 51.1% in stage III (P=0.011) and 9.1 and 0% in stage IV (P=0.005). The DFS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.857), 19.6 and 38.3% in stage III (P=0.006) and 9.1 and 0% in stage IV (P=0.700). The systemic recurrence rate was significantly higher in the low expression group compared with in the high expression group (42.7 vs. 12.9%, respectively, P=0.030). Low PD-L1 expression was significantly associated with tumor relapse and poor prognosis in stage III CRC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Spandidos Publications | - |
dc.relation.isPartOf | Oncology Letters | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prognostic impact of programmed cell death ligand 1 expression on long-term oncologic outcomes in colorectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sung Uk Bae | - |
dc.contributor.googleauthor | Woon Kyung Jeong | - |
dc.contributor.googleauthor | Seong Kyu Baek | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Ilseon Hwang | - |
dc.identifier.doi | 10.3892/ol.2018.9264 | - |
dc.contributor.localId | A00353 | - |
dc.relation.journalcode | J02417 | - |
dc.identifier.eissn | 1792-1082 | - |
dc.identifier.pmid | 30250590 | - |
dc.subject.keyword | colorectal neoplasms | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | programmed cell death 1 receptor | - |
dc.subject.keyword | survival analysis | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 5214 | - |
dc.citation.endPage | 5222 | - |
dc.identifier.bibliographicCitation | Oncology Letters, Vol.16(4) : 5214-5222, 2018 | - |
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