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Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

DC Field Value Language
dc.contributor.author정재호-
dc.contributor.author박기청-
dc.contributor.author이재은-
dc.contributor.author조재용-
dc.contributor.author임재윤-
dc.contributor.author노성훈-
dc.date.accessioned2019-09-20T07:24:45Z-
dc.date.available2019-09-20T07:24:45Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170876-
dc.description.abstractGastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNature Communications-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHDrug Resistance, Neoplasm-
dc.subject.MESHEpithelial-Mesenchymal Transition-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Stromal Tumors/drug therapy-
dc.subject.MESHGastrointestinal Stromal Tumors/genetics*-
dc.subject.MESHGastrointestinal Stromal Tumors/metabolism-
dc.subject.MESHGastrointestinal Stromal Tumors/pathology*-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHHeterografts-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMesoderm/pathology*-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMicrosatellite Instability-
dc.subject.MESHMutation-
dc.subject.MESHPrognosis-
dc.subject.MESHProteomics-
dc.subject.MESHReceptor, IGF Type 1/metabolism-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSignal Transduction-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.titleClinical and genomic landscape of gastric cancer with a mesenchymal phenotype-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSang Cheul Oh-
dc.contributor.googleauthorBo Hwa Sohn-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorSang-Bae Kim-
dc.contributor.googleauthorJae Eun Lee-
dc.contributor.googleauthorKi Cheong Park-
dc.contributor.googleauthorSang Ho Lee-
dc.contributor.googleauthorJong-Lyul Park-
dc.contributor.googleauthorYun-Yong Park-
dc.contributor.googleauthorHyun-Sung Lee-
dc.contributor.googleauthorHee-Jin Jang-
dc.contributor.googleauthorEun Sung Park-
dc.contributor.googleauthorSang-Cheol Kim-
dc.contributor.googleauthorJeonghoon Heo-
dc.contributor.googleauthorIn-Sun Chu-
dc.contributor.googleauthorYou-Jin Jang-
dc.contributor.googleauthorYoung-Jae Mok-
dc.contributor.googleauthorWonKyung Jung-
dc.contributor.googleauthorBaek-Hui Kim-
dc.contributor.googleauthorAeree Kim-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorYuki Hayashi-
dc.contributor.googleauthorShumei Song-
dc.contributor.googleauthorElena Elimova-
dc.contributor.googleauthorJeannelyn S. Estralla-
dc.contributor.googleauthorJeffrey H. Lee-
dc.contributor.googleauthorManoop S. Bhutani-
dc.contributor.googleauthorYiling Lu-
dc.contributor.googleauthorWenbin Liu-
dc.contributor.googleauthorJeeyun Lee-
dc.contributor.googleauthorWon Ki Kang-
dc.contributor.googleauthorSung Kim-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorGordon B. Mills-
dc.contributor.googleauthorSeon-Young Kim-
dc.contributor.googleauthorJaffer A. Ajani-
dc.contributor.googleauthorJu-Seog Lee-
dc.identifier.doi10.1038/s41467-018-04179-8-
dc.contributor.localIdA03717-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid29725014-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.affiliatedAuthor정재호-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage1777-
dc.identifier.bibliographicCitationNature Communications, Vol.9(1) : 1777, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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