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Long-Term Comparison of Platinum Chromium Everolimus-Eluting Stent vs. Cobalt Chromium Zotarolimus-Eluting Stent - 3-Year Outcomes From the HOST-ASSURE Randomized Clinical Trial

 Chee Hae Kim  ;  Kyung Woo Park  ;  Jeehoon Kang  ;  Byoung-Eun Park  ;  Kwang Soo Cha  ;  Jay Young Rhew  ;  Hui-Kyung Jeon  ;  Eun-Seok Shin  ;  Ju Hyeon Oh  ;  Myung-Ho Jeong  ;  Sanghyun Kim  ;  Kyung-Kuk Hwang  ;  Jung-Han Yoon  ;  Sung Yun Lee  ;  Tae-Ho Park  ;  Keon Woong Moon  ;  Hyuck-Moon Kwon  ;  Seung-Ho Hur  ;  Jae-Kean Ryu  ;  Bong-Ryul Lee  ;  Yong Whi Park  ;  In-Ho Chae  ;  Hyo-Soo Kim 
 CIRCULATION JOURNAL, Vol.83(7) : 1489-1497, 2019 
Journal Title
Issue Date
Clinical outcome ; Cobalt chromium-based zotarolimus-eluting stent ; Drug-eluting stent ; Percutaneous coronary intervention ; Platinum chromium-based everolimus-eluting stent
BACKGROUND: There are limited data on the long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) vs. cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES).Methods and Results:A total of 3,755 patients undergoing percutaneous coronary intervention (PCI) were randomized 2:1 to PtCr-EES or CoCr-ZES, and 96.0% of patients completed the 3-year clinical follow-up. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR). At 3 years, TLF occurred in 5.3% and in 5.4% of the PtCr-EES and CoCr-ZES groups, respectively (hazard ratio 0.978; 95% confidence interval 0.730-1.310, P=0.919). There were no significant differences in the individual components of TLF. Routine angiographic follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that had follow-up angiography, the clinically-driven TLR rate of CoCr-ZES was significantly higher than PtCr-EES group during the angiography follow-up period (P=0.009). Overall definite and probable stent thrombosis rates were very low in both groups (0.5% vs. 0.6%, P=0.677). CONCLUSIONS: PtCr-EES and CoCr-ZES had similar and excellent long-term outcomes in both efficacy and safety after PCI in an all-comer population.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
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