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Retrospectively validating the results of the ACOSOG Z0011 trial in a large Asian Z0011-eligible cohort

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dc.contributor.author박세호-
dc.contributor.author조영업-
dc.date.accessioned2019-07-23T06:41:45Z-
dc.date.available2019-07-23T06:41:45Z-
dc.date.issued2019-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170275-
dc.description.abstractPURPOSE: The Z0011 trial demonstrated that axillary dissection (ALND) could be omitted during breast-conserving therapy for cT1-2N0 breast cancers with 1-2 metastatic SLNs. However, that result has not been validated in a larger cohort and the significance of the small number of SLNs remains unclear. This study aimed to validate the Z0011 results within an Asian Z0011-eligible cohort and determine whether the number of sentinel lymph nodes (SLNs) influenced the Z0011-based outcomes. METHODS: Data from Asian patients who fulfilled the Z0011 criteria were collected from five hospitals. Disease recurrence (DR) was compared between patients who underwent ALND or SLN dissection (SLND) alone. Propensity-score matching was performed to reduce the effects of potential selection biases. RESULTS: During 2010-2016, 1750 Asian patients had 1-2 SLN metastases and fulfilled the Z0011 criteria. These patients included 707 cases treated using SLND alone (40%) and 967 patients with ≤ 2 SLNs (55%). Ninety-five patients (5.4%) experienced DR at a median interval of 50 months, although the rates of DR were similar in the ALND and SLND groups. The adjusted hazard ratios for DR after ALND omission were 0.95 (95% CI 0.55-1.64) among the entire cohort and 0.83 (95% CI 0.34-2.03) among patients with ≤ 2 SLNs. CONCLUSIONS: In this Asian Z0011-eligible cohort, ALND omission did not increase risk of DR, even among patients with ≤ 2 SLNs. Therefore, the Z0011 strategy might be safely applied in Asia, and a small number of SLNs did not significantly influence this strategy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKluwer Academic-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRetrospectively validating the results of the ACOSOG Z0011 trial in a large Asian Z0011-eligible cohort-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJiwoong Jung-
dc.contributor.googleauthorWonshik Han-
dc.contributor.googleauthorEun Sook Lee-
dc.contributor.googleauthorSo-Youn Jung-
dc.contributor.googleauthorJai Hong Han-
dc.contributor.googleauthorDong-Young Noh-
dc.contributor.googleauthorYumi Kim-
dc.contributor.googleauthorHee Jun Choi-
dc.contributor.googleauthorJeong Eon Lee-
dc.contributor.googleauthorSeok Jin Nam-
dc.contributor.googleauthorJong Won Lee-
dc.contributor.googleauthorHee Jeong Kim-
dc.contributor.googleauthorEunhae Um-
dc.contributor.googleauthorJoo Heung Kim-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorYoung Up Cho-
dc.identifier.doi10.1007/s10549-019-05157-4-
dc.contributor.localIdA01524-
dc.contributor.localIdA05420-
dc.contributor.localIdA05420-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid30715659-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10549-019-05157-4-
dc.subject.keywordAxillary lymph node dissection-
dc.subject.keywordBreast cancer-
dc.subject.keywordSentinel lymph node biopsy-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor조영업-
dc.contributor.affiliatedAuthor조영업-
dc.citation.volume175-
dc.citation.number1-
dc.citation.startPage203-
dc.citation.endPage215-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.175(1) : 203-215, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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