This report presents two cases oftoothautotransplantationusing cone-beam computed tomography (CBCT), the three-dimensional (3D) simulation dental planning software and a computer-aided rapid prototyping (CARP) model. Two hopelessteethof adult patients were replaced as their third molarteeth. Before deciding theautotransplantation, diagnostic CBCT images were acquired and imported to SimPlant software. The SimPlant dental program was used for surgical simulation prior toautotransplantation, which created3Dimages of the available donorteethand recipient sitetoothand superimposed the images to display their morphological similarity. Efficient modification of the recipient socket was designed preoperatively. The CARP model of the donortoothwas prepared as a substitute for the donortooththat would be fit into the new recipient socket during bone preparation.Autotransplantationwas favourably performed in 5-6 min. Transplantedteethhealed up withoutclinicalabnormality. The postoperative follow-up time was up to 6 years.