Cited 4 times in
Low plasma renin activity is an independent predictor of near-term incidence of hypertension in Asian populations
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 박성하 | - |
dc.date.accessioned | 2019-07-23T06:35:04Z | - |
dc.date.available | 2019-07-23T06:35:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1064-1963 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170220 | - |
dc.description.abstract | BACKGROUND: Plasma renin activity is involved in the regulation of body salt content and blood pressure. However, there is a paucity of data regarding the association between low or high plasma renin activity and the development of hypertension. METHOD: We investigated the relation of baseline plasma renin activity to increases in blood pressure and the incidence of hypertension after four years in 2,146 non-hypertensive individuals from a community-based Korean population (mean age, 50 years), 58% of whom were women. We defined an "increase in blood pressure" as an increment of systolic blood-pressure ≥ 10 mmHg or initiation of antihypertensive drugs and defined "hypertension" as a systolic blood pressure of 140 mm Hg or higher, a diastolic blood pressure of 90 mm Hg or higher, or the use of antihypertensive medications. RESULTS: After 4 years, the increase in blood pressure had increased in 27.9% of the participants, and hypertension had developed in 17.9%. After adjustment, the lowest sex-specific tertile of plasma renin activity was an independent risk factor of an elevation in blood pressure (Adjusted Odds Ratio 1.37, 95% confidence interval 1.07-1.74, p = 0.011) and hypertension (Adjusted Odds Ratio 1.84, 95% confidence interval 1.36-2.50, p < 0.001) compared to the highest sex-specific tertile. The associations between the plasma renin activity and blood-pressure outcomes were evident in adults with especially high urine sodium excretion. CONCLUSION: Low plasma renin activity was associated with the development of hypertension in the middle-aged Asian population, especially in peoples with high sodium intake. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | AsianContinental Ancestry Group | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/blood | - |
dc.subject.MESH | Hypertension/epidemiology | - |
dc.subject.MESH | Hypertension/physiopathology | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Renin/blood | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Low plasma renin activity is an independent predictor of near-term incidence of hypertension in Asian populations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Eun Ho Choo | - |
dc.contributor.googleauthor | Kyoung Hwa Ha | - |
dc.contributor.googleauthor | Seung-Won Lee | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Hae Young Lee | - |
dc.contributor.googleauthor | Sang-Hyun Ihm | - |
dc.identifier.doi | 10.1080/10641963.2018.1481422 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01512 | - |
dc.relation.journalcode | J03128 | - |
dc.identifier.eissn | 1525-6006 | - |
dc.identifier.pmid | 29902069 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/10641963.2018.1481422 | - |
dc.subject.keyword | Asian | - |
dc.subject.keyword | Renin | - |
dc.subject.keyword | blood pressure | - |
dc.subject.keyword | hypertension | - |
dc.subject.keyword | sodium intake | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 330 | - |
dc.citation.endPage | 335 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL HYPERTENSION, Vol.41(4) : 330-335, 2019 | - |
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