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Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model

Authors
 Jung Bok Lee  ;  Jeong Su Park  ;  Young Min Shin  ;  Da Hyun Lee  ;  Jeong‐Kee Yoon  ;  Dae‐Hyun Kim  ;  Ung Hyun Ko  ;  YongTae Kim  ;  Soo Han Bae  ;  Hak‐Joon Sung 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.29(23) : 1900075, 2019 
Journal Title
 ADVANCED FUNCTIONAL MATERIALS 
ISSN
 1616-301X 
Issue Date
2019
Keywords
3D vascular network ; animal model ; liver bud ; liver chip ; nonalcoholic fatty liver disease
Abstract
Artificial liver models have been extensively developed for pathological modeling and toxicological studies. However, the prediction of existing in vitro liver models rarely corresponds to what is consequently observed in vivo owing to the structural and functional complexity of the liver. Here, a new liver model designed to enable the implantation and maintenance of liver buds in perfusable 3D hydrogels where a microvascular network develops within a 200 µm diffusion limit is developed. This system replicates inflammation, lipid accumulation, and fibrosis during the progressive processes of nonalcoholic fatty liver disease, in which this model predicted the results from a mouse model. This model reveals that a hepatic steatosis‐reducing drug restored mitochondrial activities with significant reduction of inflammation, oxidative stress, and lipid accumulation. This liver model is not only highly predictive but also scalable and easy to apply to high‐throughput drug screening and implantation studies, suggesting a promising alternative to animal models.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201900075
DOI
10.1002/adfm.201900075
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Dae-Hyun(김대현)
Park, Jeong Su(박정수) ORCID logo https://orcid.org/0000-0003-4551-4294
Bae, Soo Han(배수한) ORCID logo https://orcid.org/0000-0002-8007-2906
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170213
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