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Inflammasome-Mediated Inflammation in Neurodegenerative Diseases

Authors
 Jun Young Park  ;  Yeo Wool Kang  ;  Won Gil Cho 
Citation
 Open Neurology Journal, Vol.13 : 55-62, 2019 
Journal Title
 Open Neurology Journal 
ISSN
 1874-205X 
Issue Date
2019
Keywords
Alzheimer’s disease ; Amyotrophic lateral sclerosis ; Multiple sclerosis ; Inflammasome ; NLRP3 ; Neuroinflammation ; Parkinson’s disease.
Abstract
Inflammasomes are protein platforms consisting of multiple proteins. The biological function includes the activation of caspase-1, leading to the maturation of IL-1β and IL-18. These pro-inflammatory cytokines promote fundamental inflammatory processes in numerous infectious diseases. The inflammasome-mediated inflammation has become increasingly important in central nervous system disorders. In neurodegenerative disorders, significant contributors to disease progression include neuroinflammation and inflammatory cascades initiated by the inflammasome protein complex. This review discusses the recent progress of research on inflammasome associated with neurodegenerative disorders.
Files in This Item:
T999901568.pdf Download
DOI
10.2174/1874205X01913010055,
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
Yonsei Authors
Park, Jun Young(박준영) ORCID logo https://orcid.org/0000-0003-3403-2767
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170146
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