Cited 9 times in
Prescription Refill Gap of Endocrine Treatment from Electronic Medical Records as a Prognostic Factor in Breast Cancer Patients
DC Field | Value | Language |
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dc.contributor.author | 박유랑 | - |
dc.date.accessioned | 2019-07-11T03:40:54Z | - |
dc.date.available | 2019-07-11T03:40:54Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170086 | - |
dc.description.abstract | Purpose: Discontinuation of hormone therapy is known to lead to a poorer prognosis in breast cancer patients. We aimed to investigate the prescription gap as a prompt index of medication adherence by using prescription data extracted from patient electronic medical records. Methods: A total of 5,928 patients diagnosed with invasive, non-metastatic breast cancer, who underwent surgery from January 1, 1997 to December 31, 2009, were enrolled retrospectively. The prescription data for 4.5 years of hormonal treatment and breast cancer-related events after treatment completion were analyzed. We examined the characteristics and prognoses of breast cancer in patients with and without a 4-week gap. Results: Patients with a gap showed a significantly higher risk of breast cancer recurrence, distant metastasis, breast cancer-specific death, and overall death after adjustment (hazard ratio [HR], 1.389; 95% confidence interval [CI], 1.089-1.772; HR, 1.568; 95% CI, 1.158-2.123; HR, 2.108; 95% CI, 1.298-3.423; and HR, 2.102; 95% CI, 1.456-3.034, respectively). When patients were categorized based on gap summation, the lower third (160 days) and fourth (391 days) quartiles showed a significantly higher risk of distant metastasis (HR, 1.758; 95% CI, 1.186-2.606 and HR, 1.844; 95% CI, 1.262-2.693, respectively). Conclusion: A gap of > 4 weeks in hormonal treatment has negative effects on breast cancer prognosis, and can hence be used as a sentinel index of higher risk due to treatment non-adherence. Further evaluation is needed to determine whether the gap can be used as a universal index for monitoring the adherence to hormonal treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean, English | - |
dc.publisher | Korean Breast Cancer Society | - |
dc.relation.isPartOf | JOURNAL OF BREAST CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prescription Refill Gap of Endocrine Treatment from Electronic Medical Records as a Prognostic Factor in Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) | - |
dc.contributor.googleauthor | Yura Lee | - |
dc.contributor.googleauthor | Yu Rang Park | - |
dc.contributor.googleauthor | Ji Sung Lee | - |
dc.contributor.googleauthor | Sae Byul Lee | - |
dc.contributor.googleauthor | Il Yong Chung | - |
dc.contributor.googleauthor | Byung Ho Son | - |
dc.contributor.googleauthor | Sei Hyun Ahn | - |
dc.contributor.googleauthor | Jong Won Lee | - |
dc.identifier.doi | 10.4048/jbc.2019.22.e14 | - |
dc.contributor.localId | A05624 | - |
dc.relation.journalcode | J01279 | - |
dc.identifier.eissn | 2092-9900 | - |
dc.identifier.pmid | 30941236 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Estrogen antagonists | - |
dc.subject.keyword | Medication adherence | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.contributor.alternativeName | Park, Yu Rang | - |
dc.contributor.affiliatedAuthor | 박유랑 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 86 | - |
dc.citation.endPage | 95 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BREAST CANCER, Vol.22(1) : 86-95, 2019 | - |
dc.identifier.rimsid | 62523 | - |
dc.type.rims | ART | - |
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