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Prescription Refill Gap of Endocrine Treatment from Electronic Medical Records as a Prognostic Factor in Breast Cancer Patients

DC FieldValueLanguage
dc.contributor.author박유랑-
dc.date.accessioned2019-07-11T03:40:54Z-
dc.date.available2019-07-11T03:40:54Z-
dc.date.issued2019-
dc.identifier.issn1738-6756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170086-
dc.description.abstractPurpose: Discontinuation of hormone therapy is known to lead to a poorer prognosis in breast cancer patients. We aimed to investigate the prescription gap as a prompt index of medication adherence by using prescription data extracted from patient electronic medical records. Methods: A total of 5,928 patients diagnosed with invasive, non-metastatic breast cancer, who underwent surgery from January 1, 1997 to December 31, 2009, were enrolled retrospectively. The prescription data for 4.5 years of hormonal treatment and breast cancer-related events after treatment completion were analyzed. We examined the characteristics and prognoses of breast cancer in patients with and without a 4-week gap. Results: Patients with a gap showed a significantly higher risk of breast cancer recurrence, distant metastasis, breast cancer-specific death, and overall death after adjustment (hazard ratio [HR], 1.389; 95% confidence interval [CI], 1.089-1.772; HR, 1.568; 95% CI, 1.158-2.123; HR, 2.108; 95% CI, 1.298-3.423; and HR, 2.102; 95% CI, 1.456-3.034, respectively). When patients were categorized based on gap summation, the lower third (160 days) and fourth (391 days) quartiles showed a significantly higher risk of distant metastasis (HR, 1.758; 95% CI, 1.186-2.606 and HR, 1.844; 95% CI, 1.262-2.693, respectively). Conclusion: A gap of > 4 weeks in hormonal treatment has negative effects on breast cancer prognosis, and can hence be used as a sentinel index of higher risk due to treatment non-adherence. Further evaluation is needed to determine whether the gap can be used as a universal index for monitoring the adherence to hormonal treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean, English-
dc.publisherKorean Breast Cancer Society-
dc.relation.isPartOfJOURNAL OF BREAST CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrescription Refill Gap of Endocrine Treatment from Electronic Medical Records as a Prognostic Factor in Breast Cancer Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biomedical Systems Informatics (의생명시스템정보학교실)-
dc.contributor.googleauthorYura Lee-
dc.contributor.googleauthorYu Rang Park-
dc.contributor.googleauthorJi Sung Lee-
dc.contributor.googleauthorSae Byul Lee-
dc.contributor.googleauthorIl Yong Chung-
dc.contributor.googleauthorByung Ho Son-
dc.contributor.googleauthorSei Hyun Ahn-
dc.contributor.googleauthorJong Won Lee-
dc.identifier.doi10.4048/jbc.2019.22.e14-
dc.contributor.localIdA05624-
dc.relation.journalcodeJ01279-
dc.identifier.eissn2092-9900-
dc.identifier.pmid30941236-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordEstrogen antagonists-
dc.subject.keywordMedication adherence-
dc.subject.keywordNeoplasm metastasis-
dc.contributor.alternativeNamePark, Yu Rang-
dc.contributor.affiliatedAuthor박유랑-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage86-
dc.citation.endPage95-
dc.identifier.bibliographicCitationJOURNAL OF BREAST CANCER, Vol.22(1) : 86-95, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers

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