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Serum soluble programmed cell death protein 1 could predict the current activity and severity of antineutrophil cytoplasmic antibody-associated vasculitis: a monocentric prospective study
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2019-07-11T03:39:20Z | - |
dc.date.available | 2019-07-11T03:39:20Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170076 | - |
dc.description.abstract | OBJECTIVES: We investigated whether serum soluble programmed cell death protein 1 (sPD-1) could predict the current activity and severity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on Birmingham vasculitis activity score (BVAS) in patients with AAV. METHODS: Fifty-nine patients from a monocentric prospective cohort of AAV were included. On the same visit-day, blood samples were collected and isolated sera were stored, BVAS and other AAV-related parameters were assessed, and laboratory tests were performed. We defined the lower limit of the highest tertile of BVAS as the cut-off for severe AAV (BVAS ≥12). Serum sPD-1 was measured from stored serum samples. RESULTS: The mean age was 59.7 years (38 women). The mean BVAS was 8.9 and 18 patients had severe BVAS. Patients with severe AAV exhibited the higher mean serum sPD-1 than those without (380.7 pg/mL vs. 180.3 pg/mL). Serum sPD-1 (r=0.367), white blood cell count (r=0.288), haemoglobin (r=-0.590), serum albumin (r=-0.670) erythrocyte sedimentation rate (ESR) (r=0.339) and C-reactive protein (CRP) (r=0.450) were significantly correlated with BVAS. Moreover, serum sPD-1 was meaningfully correlated with haemoglobin and serum albumin, but not ESR or CRP. In the multivariable linear regression analysis, only serum sPD-1 was significantly associated with BVAS (standardised β 0.274, p=0.024). We calculated the optimal cut-off of serum sPD-1 for severe AAV as 70.1 pg/mL. Severe AAV were more frequently identified in patients with serum sPD-1 ≥70.1 pg/mL than those without (RR 13.867). CONCLUSIONS: Serum sPD-1 could predict the current activity and severity of AAV. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Clinical And Experimental Rheumatology S.A.S | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/blood | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/pathology | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic* | - |
dc.subject.MESH | Apoptosis Regulatory Proteins* | - |
dc.subject.MESH | Blood Sedimentation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Serum soluble programmed cell death protein 1 could predict the current activity and severity of antineutrophil cytoplasmic antibody-associated vasculitis: a monocentric prospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | T. Yoon | - |
dc.contributor.googleauthor | S.S. Ahn | - |
dc.contributor.googleauthor | S.M. Jung | - |
dc.contributor.googleauthor | J.J. Song | - |
dc.contributor.googleauthor | Y.-B. Park | - |
dc.contributor.googleauthor | S.-W. Lee | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J00555 | - |
dc.identifier.eissn | 1593-098X | - |
dc.identifier.pmid | 30873951 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 정승민 | - |
dc.citation.volume | 37 | - |
dc.citation.number | Suppl. 117 | - |
dc.citation.startPage | S116 | - |
dc.citation.endPage | S121 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.37(Suppl. 117) : S116-S121, 2019 | - |
dc.identifier.rimsid | 64476 | - |
dc.type.rims | ART | - |
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