Cited 2 times in
Clinical Significance of Multiparametric Magnetic Resonance Imaging as a Preoperative Predictor of Oncologic Outcome in Very Low-Risk Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | 고동훈 | - |
dc.contributor.author | 이종수 | - |
dc.contributor.author | 장원식 | - |
dc.contributor.author | 정두용 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 홍창희 | - |
dc.date.accessioned | 2019-07-11T03:35:52Z | - |
dc.date.available | 2019-07-11T03:35:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170052 | - |
dc.description.abstract | Currently, multiparametric magnetic resonance imaging (mpMRI) is not an indication for patients with very low-risk prostate cancer. In this study, we aimed to evaluate the usefulness of mpMRI as a diagnostic tool in these patients. We retrospectively analyzed the clinical and pathological data of individuals with very low-risk prostate cancer, according to the NCCN guidelines, who underwent mpMRI before radical prostatectomy at our institution between 2010 and 2016. Patients who did not undergo pre-evaluation with mpMRI were excluded. We analyzed the factors associated with biochemical recurrence (BCR) using Cox regression model, logistic regression analysis, and Kaplan⁻Meier curve. Of 253 very low-risk prostate cancer patients, we observed 26 (10.3%) with BCR during the follow-up period in this study. The median follow-up from radical prostatectomy was 53 months (IQR 33⁻74). The multivariate Cox regression analyses demonstrated that the only factor associated with BCR in very low-risk patients was increase in the pathologic Gleason score (GS) (HR: 2.185, p-value 0.048). In addition, multivariate logistic analyses identified prostate specific antigen (PSA) (OR: 1.353, p-value 0.010), PSA density (OR: 1.160, p-value 0.013), and suspicious lesion on mpMRI (OR: 1.995, p-value 0.019) as the independent preoperative predictors associated with the pathologic GS upgrade. In our study, the pathologic GS upgrade after radical prostatectomy in very low-risk prostate cancer patients demonstrated a negative impact on BCR and mpMRI is a good prognostic tool to predict the pathologic GS upgrade. We believe that the implementation of mpMRI would be beneficial to determine the treatment strategy for these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical Significance of Multiparametric Magnetic Resonance Imaging as a Preoperative Predictor of Oncologic Outcome in Very Low-Risk Prostate Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Doo Yong Chung | - |
dc.contributor.googleauthor | Min Seok Kim | - |
dc.contributor.googleauthor | Jong Soo Lee | - |
dc.contributor.googleauthor | Hyeok Jun Goh | - |
dc.contributor.googleauthor | Dong Hoon Koh | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Chang Hee Hong | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.identifier.doi | 10.3390/jcm8040542 | - |
dc.contributor.localId | A05450 | - |
dc.contributor.localId | A05500 | - |
dc.contributor.localId | A05268 | - |
dc.contributor.localId | A04664 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04447 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 31010237 | - |
dc.subject.keyword | multiparametric MRI | - |
dc.subject.keyword | oncologic outcome | - |
dc.subject.keyword | preoperative predictor | - |
dc.subject.keyword | very low-risk prostate cancer | - |
dc.contributor.alternativeName | Koh, Dong Hoon | - |
dc.contributor.affiliatedAuthor | 고동훈 | - |
dc.contributor.affiliatedAuthor | 이종수 | - |
dc.contributor.affiliatedAuthor | 장원식 | - |
dc.contributor.affiliatedAuthor | 정두용 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 홍창희 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | E542 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.8(4) : E542, 2019 | - |
dc.identifier.rimsid | 62259 | - |
dc.type.rims | ART | - |
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