0 171

Cited 0 times in

Magnetic resonance imaging assessment of the substrate for hyposmia in patients with Parkinson's disease

Authors
 E.-J. Hwang  ;  D.-W. Ryu  ;  J.-E. Lee  ;  S.-H. Park  ;  H.-S. Choi  ;  J.-S. Kim 
Citation
 CLINICAL RADIOLOGY, Vol.74(6) : 489.e9-489.e15, 2019 
Journal Title
 CLINICAL RADIOLOGY 
ISSN
 0009-9260 
Issue Date
2019
Abstract
AIM: To assess whether multimodal magnetic resonance imaging (MRI) could detect neuroanatomical substrates that are distinctive to hyposmic Parkinson's disease (PD). MATERIALS AND METHODS: Among 102 PD patients, 62 were hyposmic and 40 were normosmic. For each patient, a sagittal structural three-dimensional (3D) T1-weighted image was obtained with the magnetisation-prepared rapid acquisition of the gradient-echo sequence to generate subcortical grey matter masking templates and to perform a voxel-based morphometry analysis of the subcortical grey matter volumes. A 3D multi-echo gradient sequence was run to obtain axial magnitude and phase images to produce a quantitative susceptibility map (QSM), and a diffusion-weighted image was acquired to generate an apparent diffusion coefficient (ADC) map. The volumes and average QSM and ADC values of the 15 subcortical grey matter structures were calculated, and the group differences were evaluated using a one-way analysis of covariance with age and gender as covariates. RESULTS: The QSM of the left thalamus significantly increased, while that of the right thalamus significantly decreased in hyposmia. No effects on the cortical volume changes were found other than aging. CONCLUSION: The present results suggest that accumulation of disease-related substances in the left and right thalamus and the increasing asymmetry between the two sides are associated with hyposmia in PD.
Full Text
https://www.sciencedirect.com/science/article/pii/S0009926019300935
DOI
10.1016/j.crad.2019.02.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Hyun Seok(최현석) ORCID logo https://orcid.org/0000-0003-4999-8513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170044
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links