Cited 19 times in
Identification of potential biomarkers for diagnosis of pancreatic and biliary tract cancers by sequencing of serum microRNAs
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 조중현 | - |
dc.date.accessioned | 2019-07-11T03:33:00Z | - |
dc.date.available | 2019-07-11T03:33:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170029 | - |
dc.description.abstract | BACKGROUND: Pancreatic and biliary tract cancer (PC and BTC, respectively) are difficult to diagnose because of their clinical characteristics; however, recent studies suggest that serum microRNAs (miRNAs) might be the key to developing more efficient diagnostic methods for these cancers. METHODS: We analysed the genome-wide expression of serum miRNAs in PC and BTC patients to identify novel biomarker candidates using high-throughput sequencing and experimentally validated miRNAs on clinical samples. RESULTS: Statistical and classification analysis of the serum miRNA-expression profiles of 55 patient samples showed distinguishable patterns between cancer patients and healthy controls; however, we were unable to distinguish the two cancers. We found that three of the highest performing miRNAs were capable of distinguishing cancer patients from controls, with an accuracy of 92.7%. Additionally, dysregulation of these three cancer-specific miRNAs was demonstrated in an independent sample group by quantitative reverse transcription polymerase chain reaction. CONCLUSIONS: These results suggested three candidate serum miRNAs (mir-744-5p, mir-409-3p, and mir-128-3p) as potential biomarkers for PC and BTC diagnosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC MEDICAL GENOMICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Identification of potential biomarkers for diagnosis of pancreatic and biliary tract cancers by sequencing of serum microRNAs | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kwondo Kim | - |
dc.contributor.googleauthor | DongAhn Yoo | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Kyong Joo Lee | - |
dc.contributor.googleauthor | Soo Been Park | - |
dc.contributor.googleauthor | Chanyang Kim | - |
dc.contributor.googleauthor | Jung Hyun Jo | - |
dc.contributor.googleauthor | Dawoon E. Jung | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 10.1186/s12920-019-0521-8 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03912 | - |
dc.relation.journalcode | J00362 | - |
dc.identifier.eissn | 1755-8794 | - |
dc.identifier.pmid | 31096984 | - |
dc.subject.keyword | Biliary tract cancer | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | Diagnosis | - |
dc.subject.keyword | Pancreatic cancer | - |
dc.subject.keyword | Serum miRNA | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | 송시영 | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.contributor.affiliatedAuthor | 조중현 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.identifier.bibliographicCitation | BMC MEDICAL GENOMICS, Vol.12(1) : 62, 2019 | - |
dc.identifier.rimsid | 61961 | - |
dc.type.rims | ART | - |
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