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Comparison of Characteristics and 3-Year Outcomes in Patients With Acute Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction

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dc.contributor.author강석민-
dc.date.accessioned2019-07-11T03:32:00Z-
dc.date.available2019-07-11T03:32:00Z-
dc.date.issued2019-
dc.identifier.issn1346-9843-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170019-
dc.description.abstractBACKGROUND: The clinical characteristics and outcomes of acute heart failure (AHF) according to left ventricular ejection fraction (LVEF) have not been fully elucidated, especially for patients with mid-range LVEF. We performed a comprehensive comparison of the epidemiology, patterns of in-hospital management, and clinical outcomes in AHF patients with different LVEF categories. Methods and Results: The Korean Acute Heart Failure (KorAHF) registry is a prospective multicenter cohort of hospitalized AHF patients in Korea. A total of 5,374 patients enrolled in the KorAHF registry were classified according to LVEF based on the 2016 ESC guidelines. More than half of the HF patients (58%) had reduced EF (HFrEF), 16% had mid-range EF (HFmrEF), and 25% had preserved EF (HFpEF). The HFmrEF patients showed intermediate epidemiological profiles between HFrEF and HFpEF and had a propensity to present as de-novo HF with ischemic etiology. Patients with lower LVEF had worse short-term outcomes, and the all-cause in-hospital mortality, including urgent heart transplantation, of HFrEF, HFmrEF, and HFpEF was 7.1%, 3.6%, and 3.0%, respectively. Overall, discharged AHF patients showed poor 3-year all-cause death up to 38%, which was comparable between LVEF subgroups (P=0.623). CONCLUSIONS: Each LVEF subgroup of AHF patients was a heterogeneous population with diverse characteristics, which have a significant effect on the clinical outcomes. This finding suggested that focused phenotyping of AHF patients could help identify the optimal management strategy and develop novel effective therapies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Japanese-
dc.publisherJapanese Circulation Society-
dc.relation.isPartOfCIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of Characteristics and 3-Year Outcomes in Patients With Acute Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJun Hwan Cho-
dc.contributor.googleauthorWon-Seok Choe-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorHae-Young Lee-
dc.contributor.googleauthorJieun Jang-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorJin-Oh Choi-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorMin-Seok Kim-
dc.contributor.googleauthorKyung-Kuk Hwang-
dc.contributor.googleauthorShung Chull Chae-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorKye Hun Kim-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorJae-Joong Kim-
dc.contributor.googleauthorByung-Hee Oh-
dc.identifier.doi10.1253/circj.CJ-18-0543-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ00534-
dc.identifier.eissn1347-4820-
dc.identifier.pmid30404976-
dc.subject.keywordAcute heart failure-
dc.subject.keywordLeft ventricular ejection fraction-
dc.subject.keywordOutcomes-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume83-
dc.citation.number2-
dc.citation.startPage347-
dc.citation.endPage356-
dc.identifier.bibliographicCitationCIRCULATION JOURNAL, Vol.83(2) : 347-356, 2019-
dc.identifier.rimsid62748-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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