Cited 14 times in
Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway
DC Field | Value | Language |
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dc.contributor.author | 이명식 | - |
dc.date.accessioned | 2019-07-11T03:30:00Z | - |
dc.date.available | 2019-07-11T03:30:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170001 | - |
dc.description.abstract | Renal fibrosis is the final common pathway of various renal injuries and it leads to chronic kidney disease. Recent studies reported that FOXD1-lineage pericyte plays a critical role in tubulointerstitial fibrosis (TIF). However the regulatory mechanisms remain unclear. Autophagy is a cellular process of degradation of damaged cytoplasmic components that regulates cell death and proliferation. To investigate the role of autophagy in FOXD1-lineage pericytes on renal TIF, we generated the FOXD1-lineage stromal cell-specific Atg7 deletion (Atg7△FOXD1) mice. FOXD1-lineage stromal cell-specific Atg7 deletion enhanced renal TIF through Smad-dependent transforming growth factor (TGF)-β signaling after unilateral ureteral obstruction (UUO). FOXD1-lineage stromal cell-specific Atg7 deletion increased the accumulation of interstitial myofibroblasts and enhanced the differentiation of pericytes into myofibroblasts after UUO. Peritubular capillary rarefaction was accelerated in Atg7△FOXD1 mice after UUO. Atg7△FOXD1 mice increased the accumulation of SQSTM1/p62-positive aggregates in the obstructed kidney and resulted in increased expression of NLRP3 inflammasome, interleukin (IL) 1-β and caspase-1 signaling pathway, which enhanced apoptosis of interstitial cells after UUO. In summary, our data showed that autophagy in FOXD1-lineage stromal cells plays a protective role in renal TIF through regulating the Smad4 dependent TGF-β an NLRP3 inflammasome signaling pathway. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Sun Ah Nam | - |
dc.contributor.googleauthor | Wan-Young Kim | - |
dc.contributor.googleauthor | Jin-Won Kim | - |
dc.contributor.googleauthor | Min Gyu Kang | - |
dc.contributor.googleauthor | Sang Hee Park | - |
dc.contributor.googleauthor | Myung-Shik Lee | - |
dc.contributor.googleauthor | Hyung Wook Kim | - |
dc.contributor.googleauthor | Chul Woo Yang | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | Yong Kyun Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.11.090 | - |
dc.contributor.localId | A02752 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 30545632 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X18325142 | - |
dc.subject.keyword | Autophagy | - |
dc.subject.keyword | FOXD1 | - |
dc.subject.keyword | Fibrosis | - |
dc.subject.keyword | Inflammasome | - |
dc.subject.keyword | Kidney | - |
dc.subject.keyword | Pericytes | - |
dc.contributor.alternativeName | Lee, Myung Shik | - |
dc.contributor.affiliatedAuthor | 이명식 | - |
dc.citation.volume | 508 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 965 | - |
dc.citation.endPage | 972 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.508(3) : 965-972, 2019 | - |
dc.identifier.rimsid | 62794 | - |
dc.type.rims | ART | - |
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