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Low PR in ER(+)/HER2(-) breast cancer: high rates of TP53 mutation and high SUV

Authors
 Sung Gwe Ahn  ;  Chang Ik Yoon  ;  Jae Hoon Lee  ;  Hye Sun Lee  ;  So Eun Park  ;  Yoon Jin Cha  ;  Chihwan Cha  ;  Soong June Bae  ;  Kyung-A Lee  ;  Joon Jeong 
Citation
 ENDOCRINE-RELATED CANCER, Vol.26(2) : 177-185, 2019 
Journal Title
 ENDOCRINE-RELATED CANCER 
ISSN
 1351-0088 
Issue Date
2019
Abstract
On the basis of TP53 mutations and standardized uptake values (SUVs) from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), we sought to enhance our knowledge of the biology underlying low progesterone receptor (PR) expression in estrogen receptor (ER)-positive/human epidermal growth factor receptor-2 (HER2)-negative tumors. This study included 272 patients surgically treated for ER-positive, HER2-negative breast cancer and who had undergone TP53 gene sequencing. Of these, 229 patients also underwent 18F-FDG PET or PET/CT. Mutational analysis of exons 5 to 9 of the TP53 gene was conducted using polymerase chain reaction amplification and direct sequencing. The SUVs were measured using 18F-FDG-PET scan images. We found that twenty-eight (10.3%) tumors had a somatic TP53 mutation. The TP53 mutation rate was significantly higher in low-PR tumors than in high-PR tumors (17.1% vs. 7.9%, P = 0.039). Low-PR tumors had significantly higher median SUVs than high-PR tumors (P = 0.046). The multivariable analysis revealed that SUV and age remained independent variables associated with low PR expression. An adverse impact of low PR expression on recurrence-free survival was observed in the multivariable Cox regression hazard model. We provide clinical evidence that genetic alteration of the TP53 gene and dysregulated glucose metabolism partly involve low PR expression in ER-positive and HER2-negative breast cancer.
Files in This Item:
T201901594.pdf Download
DOI
10.1530/ERC-18-0281
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, So Eun(박소은)
Bae, Soong June(배숭준) ORCID logo https://orcid.org/0000-0002-0012-9694
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Cha, Chi Hwan(차치환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169982
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