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Incorporation of paclitaxel-based hyperthermic intraperitoneal chemotherapy in patients with advanced-stage ovarian cancer treated with neoadjuvant chemotherapy followed by interval debulking surgery: a protocol-based pilot study

DC Field Value Language
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author남은지-
dc.contributor.author이용재-
dc.contributor.author이정윤-
dc.contributor.author조민수-
dc.date.accessioned2019-07-11T03:25:29Z-
dc.date.available2019-07-11T03:25:29Z-
dc.date.issued2019-
dc.identifier.issn2005-0380-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169969-
dc.description.abstractOBJECTIVES: We conducted a protocol-based cohort study to evaluate the outcomes of interval debulking surgery (IDS) followed by paclitaxel-based hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of advanced-stage ovarian cancer. METHODS: From October 2015 to May 2018, 65 patients with stages IIIC-IV ovarian cancer were treated according to the study protocol. HIPEC was performed with paclitaxel (175 mg/m²) for 90 minutes, only in cases of optimal cytoreduction. RESULTS: Of 65 patients, 40 (61.5%) patients underwent neoadjuvant chemotherapy (NAC), 34 (52.3%) patients had a high tumor burden with a Fagotti score ≥8 at diagnostic laparoscopy, and 6 (9.2%) had definite stage IV metastasis and/or poor performance status before NAC. Twenty-seven (41.5%) patients underwent IDS followed by HIPEC. The mean duration of IDS with HIPEC was 543.8 (range, 277.0-915.0) minutes. Grade III/IV perioperative complications occurred in 7.4% (n=2)/3.7% (n=1) of patients and no cases of mortality were reported within 30 days postoperatively. The median progression-free survival was 21.3 months, and the median overall survival was not reached for those who received HIPEC. CONCLUSIONS: According to our study protocol, IDS followed by paclitaxel-based HIPEC as a first-line treatment appears to be feasible and safe for the treatment of advanced-stage ovarian cancer. Further evaluations of this procedure are required to assess its survival benefits.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAsian Society of Gynecologic Oncology : Taehan Puin Chongyang Hakhoe-
dc.relation.isPartOfJOURNAL OF GYNECOLOGIC ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIncorporation of paclitaxel-based hyperthermic intraperitoneal chemotherapy in patients with advanced-stage ovarian cancer treated with neoadjuvant chemotherapy followed by interval debulking surgery: a protocol-based pilot study-
dc.title.alternative.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorYong Jae Lee-
dc.contributor.googleauthorJung-Yun Lee-
dc.contributor.googleauthorMin-Soo Cho-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.3802/jgo.2019.30.e3-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA05165-
dc.contributor.localIdA04638-
dc.contributor.localIdA03817-
dc.relation.journalcodeJ01428-
dc.identifier.eissn2005-0399-
dc.identifier.pmid30479087-
dc.subject.keywordDrug Therapy-
dc.subject.keywordHyperthermic Intraperitoneal Chemotherapy-
dc.subject.keywordOvarian Neoplasms-
dc.subject.keywordPaclitaxel-
dc.subject.keywordSurgery-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.affiliatedAuthor김상운-
dc.contributor.affiliatedAuthor김성훈-
dc.contributor.affiliatedAuthor김영태-
dc.contributor.affiliatedAuthor남은지-
dc.contributor.affiliatedAuthor이용재-
dc.contributor.affiliatedAuthor이정윤-
dc.contributor.affiliatedAuthor조민수-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPagee3-
dc.identifier.bibliographicCitationJOURNAL OF GYNECOLOGIC ONCOLOGY, Vol.30(1) : e3, 2019-
dc.identifier.rimsid62876-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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