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The Effect of Dilution with 10% Dextrose Solution on the Potency of Botulinum Toxin A
DC Field | Value | Language |
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dc.contributor.author | 권정승 | - |
dc.contributor.author | 조은애산드라 | - |
dc.contributor.author | 최종훈 | - |
dc.date.accessioned | 2019-07-11T03:24:27Z | - |
dc.date.available | 2019-07-11T03:24:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2288-9272 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169963 | - |
dc.description.abstract | Purpose: The aim of this study was to compare the potency-stabilizing effects of two different diluents of botulinum toxin A (10% dextrose solution and 0.9% saline). Methods: A mouse lethality bioassay was undertaken. Ninety mice were divided into experimental and control groups which received varying dosages in subgroups of 10. The experimental group was injected with botulinum toxin A diluted with 10% dextrose solution and the control group was injected with botulinum toxin A diluted with 0.9% saline. A 72 hours after intraperitoneal injection, the number of dead mice was counted to confirm median lethal dose (LD50) of each group. Results: The value of LD50 in the experimental group was approximately 0.131 mL (1.31 U) and the value of LD50 in the control group was approximately 0.107 mL (1.07 U). The potency preservation rate of the experimental group was estimated to be 93.5% and that of the control group was estimated to be 76.3%. Conclusions: Dilution with 10% dextrose solution displayed less potency loss than 0.9% saline. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Academy of Orofacial Pain and Oral Medicine | - |
dc.relation.isPartOf | Journal of Oral Medicine and Pain | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The Effect of Dilution with 10% Dextrose Solution on the Potency of Botulinum Toxin A | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) | - |
dc.contributor.googleauthor | Jong Wook Ham | - |
dc.contributor.googleauthor | Jeong-Seung Kwon | - |
dc.contributor.googleauthor | Eunae Sandra Cho | - |
dc.contributor.googleauthor | Jong Hoon Choi | - |
dc.identifier.doi | 10.14476/jomp.2019.44.1.11 | - |
dc.contributor.localId | A00249 | - |
dc.contributor.localId | A04799 | - |
dc.contributor.localId | A04188 | - |
dc.relation.journalcode | J01664 | - |
dc.identifier.eissn | 2383-8493 | - |
dc.subject.keyword | Botulinum toxins, Type A | - |
dc.subject.keyword | Glucose | - |
dc.subject.keyword | Saline solution | - |
dc.contributor.alternativeName | Kwon, Jeong Seung | - |
dc.contributor.affiliatedAuthor | 권정승 | - |
dc.contributor.affiliatedAuthor | 조은애산드라 | - |
dc.contributor.affiliatedAuthor | 최종훈 | - |
dc.citation.volume | 44 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 11 | - |
dc.citation.endPage | 15 | - |
dc.identifier.bibliographicCitation | Journal of Oral Medicine and Pain, Vol.44(1) : 11-15, 2019 | - |
dc.identifier.rimsid | 63056 | - |
dc.type.rims | ART | - |
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