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The Effect of Dilution with 10% Dextrose Solution on the Potency of Botulinum Toxin A

Authors
 Jong Wook Ham  ;  Jeong-Seung Kwon  ;  Eunae Sandra Cho  ;  Jong Hoon Choi 
Citation
 Journal of Oral Medicine and Pain, Vol.44(1) : 11-15, 2019 
Journal Title
 Journal of Oral Medicine and Pain 
ISSN
 2288-9272 
Issue Date
2019
Keywords
Botulinum toxins, Type A ; Glucose ; Saline solution
Abstract
Purpose: The aim of this study was to compare the potency-stabilizing effects of two different diluents of botulinum toxin A (10% dextrose solution and 0.9% saline). Methods: A mouse lethality bioassay was undertaken. Ninety mice were divided into experimental and control groups which received varying dosages in subgroups of 10. The experimental group was injected with botulinum toxin A diluted with 10% dextrose solution and the control group was injected with botulinum toxin A diluted with 0.9% saline. A 72 hours after intraperitoneal injection, the number of dead mice was counted to confirm median lethal dose (LD50) of each group. Results: The value of LD50 in the experimental group was approximately 0.131 mL (1.31 U) and the value of LD50 in the control group was approximately 0.107 mL (1.07 U). The potency preservation rate of the experimental group was estimated to be 93.5% and that of the control group was estimated to be 76.3%. Conclusions: Dilution with 10% dextrose solution displayed less potency loss than 0.9% saline.
Files in This Item:
T201901574.pdf Download
DOI
10.14476/jomp.2019.44.1.11
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jeong Seung(권정승) ORCID logo https://orcid.org/0000-0003-4584-7355
Cho, Eunae(조은애산드라) ORCID logo https://orcid.org/0000-0002-0820-3019
Choi, Jong Hoon(최종훈) ORCID logo https://orcid.org/0000-0003-3211-3619
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169963
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