Cited 8 times in
Pathological Characteristics of Prostate Cancer in Men Aged < 50 Years Treated with Radical Prostatectomy: a Multi-Centre Study in Korea
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2019-07-11T03:17:01Z | - |
dc.date.available | 2019-07-11T03:17:01Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169906 | - |
dc.description.abstract | Background: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (<50 years) with PCa among the Korean population, paying attention to pathological characteristics on RP specimen and biochemical recurrence (BCR). Methods: The multi-centre, Severance Urological Oncology Group registry was utilized to identify 622 patients with clinically localized or locally advanced PCa, who were treated with RP between 2001 and 2017. Patients were dichotomized into two groups according to age (< 50-year-old [n = 75] and ≥ 50-year-old [n = 547]), and clinicopathological characteristics were analysed. Propensity score matching was used when assessing BCR between the two groups. Results: Although biopsy Gleason score (GS) was lower in younger patients (P = 0.033), distribution of pathologic GS was similar between the two groups (13.3% vs. 13.9% for GS ≥ 8, P = 0.191). There was no significant difference in pathologic T stage between the < 50- and ≥ 50-year-old groups (69.3% vs. 68.0% in T2 and 30.7% vs. 32.0% in ≥ T3, P = 0.203). The positive surgical margin rates were similar between the two groups (20.0% vs. 27.6%, P = 0.178). BCR-free survival rates were also similar (P = 0.644) between the two groups, after propensity matching. Conclusion: Contrary to prior reports, younger PCa patients did not have more favourable pathologic features on RP specimen and showed similar BCR rates compared to older men. These findings should be considered when making treatment decisions for young Korean patients with PCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Prostate-Specific Antigen/blood | - |
dc.subject.MESH | Prostatectomy | - |
dc.subject.MESH | Prostatic Neoplasms/mortality | - |
dc.subject.MESH | Prostatic Neoplasms/pathology* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Pathological Characteristics of Prostate Cancer in Men Aged < 50 Years Treated with Radical Prostatectomy: a Multi-Centre Study in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Mun Su Chung | - |
dc.contributor.googleauthor | Myungsun Shim | - |
dc.contributor.googleauthor | Jin Seon Cho | - |
dc.contributor.googleauthor | Woojin Bang | - |
dc.contributor.googleauthor | Sun Il Kim | - |
dc.contributor.googleauthor | Sung Yong Cho | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.identifier.doi | 10.3346/jkms.2019.34.e78 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 30886549 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Prostatectomy | - |
dc.subject.keyword | Prostatic Neoplasms | - |
dc.subject.keyword | Young Adults | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 이승환 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.contributor.affiliatedAuthor | 홍성준 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | e78 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.34(10) : e78, 2019 | - |
dc.identifier.rimsid | 62467 | - |
dc.type.rims | ART | - |
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