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Current trends in the features of male thyroid cancer: Retrospective evaluation of their prognostic value

 Min Jhi Kim  ;  Seul Gi Lee  ;  Kwangsoon Kim  ;  Cho Rok Lee  ;  Sang-Wook Kang  ;  Jandee Lee  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Jong Ju Jeong 
 MEDICINE, Vol.98(19) : e15559, 2019 
Journal Title
Issue Date
Adult ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis/diagnosis ; Prognosis ; Retrospective Studies ; Risk Factors ; Sex Factors ; Survival Analysis ; Thyroid Cancer, Papillary/diagnosis* ; Thyroid Cancer, Papillary/epidemiology* ; Thyroid Cancer, Papillary/pathology ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/diagnosis* ; Thyroid Neoplasms/epidemiology* ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy
This study aimed to compare the clinicopathologic characteristics and oncologic outcomes of papillary thyroid cancer (PTC) patients according to sex. Then, we validated prognostic variables to determine whether sex is a significant prognostic factor for PTC.Between January 2007 and December 2010, 1232 men and 7276 women PTC patients underwent surgery. The patient characteristics and 5-year oncologic outcomes were compared. The stepwise Cox proportional hazards model determined the significance of survival variables.Men PTC patients had more lymph node (LN) metastases than women, both in the total (P < .0001) and hemithyroidectomy (P < .0001) patients. Men and women showed similar 5-year recurrence-free survivals, both in total (P = .815) and hemithyroidectomy (P = .148) patients. The tumor size and the number of positive central nodes were associated with tumor recurrence, but not sex.Sex was not an independent prognostic factor for tumor recurrence. Multicenter clinical studies with long-term follow-ups are needed to validate these results.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kim, Kwang Soon(김광순)
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Chung, Woung Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
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