Cited 9 times in
Prognostic Effect of Guideline-Directed Therapy Is More Noticeable Early in the Course of Heart Failure
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.date.accessioned | 2019-07-11T03:09:27Z | - |
dc.date.available | 2019-07-11T03:09:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169860 | - |
dc.description.abstract | BACKGROUND: There have been few studies to evaluate the prognostic implications of guideline-directed therapy according to the temporal course of heart failure. This study assessed the relationship between adherence to guideline-directed therapy at discharge and 60-day clinical outcomes in de novo acute heart failure (AHF) and acute decompensated chronic heart failure (ADCHF) separately. METHODS: Among 5,625 AHF patients who were recruited from a multicenter cohort registry of Korean Acute Heart Failure, 2,769 patients with reduced ejection fraction were analyzed. Guideline-directed therapies were defined as the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor II blocker (ARB), β-blocker, and mineralocorticoid receptor antagonist. RESULTS: In de novo AHF, ACEI or ARB reduced re-hospitalization (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.34-0.95), mortality (HR, 0.41; 95% CI, 0.24-0.69) and composite endpoint (HR, 0.52; 95% CI, 0.36-0.77) rates. Beta-blockers reduced re-hospitalization (HR, 0.62; 95% CI, 0.41-0.95) and composite endpoint (HR, 0.65; 95% CI, 0.47-0.90) rates. In ADCHF, adherence to ACEI or ARB was associated with only mortality and β-blockers with composite endpoint. CONCLUSION: The prognostic implications of adherence to guideline-directed therapy at discharge were more pronounced in de novo heart failure. We recommend that guideline-directed therapy be started as early as possible in the course of heart failure with reduced ejection fraction. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prognostic Effect of Guideline-Directed Therapy Is More Noticeable Early in the Course of Heart Failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Min-Soo Ahn | - |
dc.contributor.googleauthor | Byung-Su Yoo | - |
dc.contributor.googleauthor | Junghan Yoon | - |
dc.contributor.googleauthor | Seung-Hwan Lee | - |
dc.contributor.googleauthor | Jang-Young Kim | - |
dc.contributor.googleauthor | Sung Gyun Ahn | - |
dc.contributor.googleauthor | Young Jin Youn | - |
dc.contributor.googleauthor | Jun-Won Lee | - |
dc.contributor.googleauthor | Jung-Woo Son | - |
dc.contributor.googleauthor | Hye Sim Kim | - |
dc.contributor.googleauthor | Dae Ryong Kang | - |
dc.contributor.googleauthor | Sang Eun Lee | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.contributor.googleauthor | Myeong-Chan Cho | - |
dc.identifier.doi | 10.3346/jkms.2019.34.e133 | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 31050223 | - |
dc.subject.keyword | Acute Decompensated Heart Failure | - |
dc.subject.keyword | De Novo Acute Heart Failure | - |
dc.subject.keyword | Guideline-Directed Therapy | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | e133 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.34(17) : e133, 2019 | - |
dc.identifier.rimsid | 61993 | - |
dc.type.rims | ART | - |
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