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Effects of dexmedetomidine on inflammatory mediators after tourniquet-induced ischemia-reperfusion injury: a randomized, double-blinded, controlled study

DC Field Value Language
dc.contributor.author김도형-
dc.contributor.author김승현-
dc.contributor.author김태림-
dc.contributor.author신서경-
dc.contributor.author최용선-
dc.date.accessioned2019-07-11T03:06:30Z-
dc.date.available2019-07-11T03:06:30Z-
dc.date.issued2019-
dc.identifier.issn0375-9393-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169844-
dc.description.abstractBACKGROUND: Tourniquet use during total knee arthroplasty (TKA) produces ischemia-reperfusion injury (IRI), with systemic release of inflammatory cytokines and reactive oxygen species upon tourniquet release. We conducted a randomized, placebo-controlled, double-blind trial to examine whether dexmedetomidine (DEX) as an adjunct during general anesthesia in patients undergoing unilateral TKA could attenuate the rise in inflammatory cytokines and oxidative stress. METHODS: Sixty-eight patients were randomized to either the control or DEX group. DEX was administered at a loading dose of 0.5 μg/kg, followed by an infusion of 0.4 μg/kg/h. We measured serum levels of malondialdehyde (biomarker of oxidative stress) and proinflammatory cytokines (interleukin-6 [IL-6] and tumour necrosis factor-α [TNF-α]) preinduction (baseline), 60 and 90 min post-tourniquet release. We also assessed hemodynamics, intraoperative remifentanil consumption, and postoperative pain scores and analgesic consumption. RESULTS: Malondialdehyde was higher than baseline after tourniquet release in both groups (P≤0.001), but the levels were similar between groups at all times. TNF-α was significantly higher than baseline at 60 min post-tourniquet release only in the control group (P=0.009). Serum IL-6 increased significantly above baseline at 60 and 90 min post-tourniquet release in both groups (P<0.001). At 90 min, IL-6 was significantly lower in the dexmedetomidine group than in the control group (P=0.049). Remifentanil consumption, heart rate, and pain scores were significantly lower in the dexmedetomidine group. CONCLUSIONS: Our results suggest that dexmedetomidine as an adjunct to general anesthesia attenuated the rise in proinflammatory cytokines, providing protective effects in tourniquet-induced IRI.-
dc.description.statementOfResponsibilityrestriction-
dc.languageItalian, English-
dc.publisherEdizioni Minerva Medica-
dc.relation.isPartOfMINERVA ANESTESIOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of dexmedetomidine on inflammatory mediators after tourniquet-induced ischemia-reperfusion injury: a randomized, double-blinded, controlled study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorSeung H. KIM-
dc.contributor.googleauthorDo-Hyeong KIM-
dc.contributor.googleauthorSeokyung SHIN-
dc.contributor.googleauthorSeon J. KIM-
dc.contributor.googleauthorTae L. KIM-
dc.contributor.googleauthorYong S. CHOI-
dc.identifier.doi10.23736/S0375-9393.18.13015-X-
dc.contributor.localIdA00390-
dc.contributor.localIdA05098-
dc.contributor.localIdA05098-
dc.contributor.localIdA05564-
dc.contributor.localIdA05564-
dc.contributor.localIdA02109-
dc.contributor.localIdA02109-
dc.contributor.localIdA04119-
dc.contributor.localIdA04119-
dc.relation.journalcodeJ02235-
dc.identifier.eissn1827-1596-
dc.identifier.pmid30207136-
dc.identifier.urlhttps://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2019N03A0279-
dc.contributor.alternativeNameKim, Do Hyeong-
dc.contributor.affiliatedAuthor김도형-
dc.contributor.affiliatedAuthor김승현-
dc.contributor.affiliatedAuthor김승현-
dc.contributor.affiliatedAuthor김태림-
dc.contributor.affiliatedAuthor김태림-
dc.contributor.affiliatedAuthor신서경-
dc.contributor.affiliatedAuthor신서경-
dc.contributor.affiliatedAuthor최용선-
dc.contributor.affiliatedAuthor최용선-
dc.citation.volume85-
dc.citation.number3-
dc.citation.startPage279-
dc.citation.endPage287-
dc.identifier.bibliographicCitationMINERVA ANESTESIOLOGICA, Vol.85(3) : 279-287, 2019-
dc.identifier.rimsid62543-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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