0 371

Cited 6 times in

Outcomes After Predischarge Initiation of β-Blocker in Patients Hospitalized for Severe Decompensated Heart Failure Requiring Inotropic Therapy

DC Field Value Language
dc.contributor.author강석민-
dc.date.accessioned2019-07-11T02:58:18Z-
dc.date.available2019-07-11T02:58:18Z-
dc.date.issued2018-
dc.identifier.issn0828-282X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169793-
dc.description.abstractBACKGROUND: The optimal time for initiating β-blocker (BB) treatment in patients with severe acute decompensated heart failure requiring inotropic therapy has not been well defined. We evaluated the effect of predischarge initiation of BB treatment on clinical outcomes. METHODS: Among the 5625 patients enrolled in the Korean Acute Heart Failure (KorAHF) registry, 672 BB-naive patients suffering from heart failure with reduced ejection fraction (median, 67.0 years; 62.5% male; median left ventricular ejection fraction, 24.1%) who received inotropic support during hospitalization were evaluated. We compared the risk of post-discharge mortality and rehospitalization between groups with (n = 282) and without (n = 390) pre-discharge BB treatment. RESULTS: During a median follow-up of 2.6 years, all-cause mortality occurred in 252 patients (37.5%). Those who received pre-discharge BB treatment showed lower 2-year mortality rates compared with those who did not (21.3% vs 39.3%; P < 0.001). In a Cox proportional hazards model, all-cause mortality was consistently lower in pre-discharge BB groups after multivariable adjustment (hazard ratio, 0.69; 95% confidence interval, 0.50-0.95; P = 0.025) and adjustment for propensity score methods using the inverse probability of treatment weighting (hazard ratio, 0.70; 95% confidence interval, 0.52-0.93; P = 0.016). The same trend was observed for secondary outcomes of rehospitalization for any cause and rehospitalization for heart failure. Pre-discharge BB was associated with higher rates of BB prescription after 6 (90.1% vs 23.9%; P < 0.001) and 12 (88.9% vs 25.0%; P < 0.001) months. CONCLUSIONS: Pre-discharge BB initiation is associated with better clinical outcomes after severe acute decompensated heart failure episodes requiring inotropic therapy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCANADIAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenergic beta-Antagonists/administration & dosage*-
dc.subject.MESHAged-
dc.subject.MESHCardiotonic Agents/therapeutic use-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHeart Failure*/diagnosis-
dc.subject.MESHHeart Failure*/drug therapy-
dc.subject.MESHHeart Failure*/mortality-
dc.subject.MESHHeart Failure*/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMortality-
dc.subject.MESHOutcome Assessment (Health Care)-
dc.subject.MESHPatient Discharge/statistics & numerical data*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHStroke Volume/drug effects*-
dc.subject.MESHVentricular Dysfunction, Left*/diagnosis-
dc.subject.MESHVentricular Dysfunction, Left*/drug therapy-
dc.subject.MESHVentricular Dysfunction, Left*/etiology-
dc.titleOutcomes After Predischarge Initiation of β-Blocker in Patients Hospitalized for Severe Decompensated Heart Failure Requiring Inotropic Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMin Soo Cho-
dc.contributor.googleauthorMin-Seok Kim-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorHyo-In Choi-
dc.contributor.googleauthorJung-Bok Lee-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorHae-Young Lee-
dc.contributor.googleauthorJin-Oh Choi-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorKyung-Kuk Hwang-
dc.contributor.googleauthorShung Chul Chae-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorYoungkeun Ahn-
dc.contributor.googleauthorKye-Hoon Kim-
dc.contributor.googleauthorHyun-Young Park-
dc.contributor.googleauthorMyeong-Chan Cho MD-
dc.contributor.googleauthorByung-Hee Oh-
dc.identifier.doi10.1016/j.cjca.2018.05.005-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ00427-
dc.identifier.eissn1916-7075-
dc.identifier.pmid30170669-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0828282X18303738-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume34-
dc.citation.number9-
dc.citation.startPage1145-
dc.citation.endPage1152-
dc.identifier.bibliographicCitationCANADIAN JOURNAL OF CARDIOLOGY, Vol.34(9) : 1145-1152, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.