42 65

Cited 5 times in

Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis

Authors
 Xin Wang  ;  Zane Gray  ;  Jami Willette-Brown  ;  Feng Zhu  ;  Gongping Shi  ;  Qun Jiang  ;  Na-Young Song  ;  Liang Dong  ;  Yinling Hu 
Citation
 CELL DEATH DISCOVERY, Vol.4(46), 2018 
Journal Title
 CELL DEATH DISCOVERY 
Issue Date
2018
Abstract
Human lung squamous cell carcinoma (SCC) is highly associated with increased pulmonary macrophage infiltration. Previously, we showed that marked pulmonary infiltrating macrophages were required for spontaneous lung SCC development in a mouse model (L-IkkαKA/KA , KA/KA) that resembles human lung SCC. Interestingly the lung SCC-associated macrophages specifically express elevated inducible nitric oxide synthase (NOS2). However, the role of macrophage NOS2 in lung carcinogenesis has not been explored. Here, we show that NOS2 ablation inhibits macrophage infiltration, fibrosis, and SCC development in the lungs of KA/KA mice. Macrophage NOS2 was found to circulate inflammation and enhance macrophage migration and survival. NOS2 promotes foamy macrophage formation characterized with impaired lipid metabolism. NOS2 null bone marrow transplantation reduces foamy macrophage numbers and carcinogenesis in KA/KA chimaeras. This finding sheds light on a new mechanism by which macrophage NOS2 increases pulmonary inflammatory responses and macrophage survival and impairs macrophage lipid metabolism, thereby promoting lung SCC formation.
Files in This Item:
T201805958.pdf Download
DOI
10.1038/s41420-018-0046-5
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Song, Na-Young(송나영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169788
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse