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ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2019-05-29T05:24:51Z-
dc.date.available2019-05-29T05:24:51Z-
dc.date.issued2019-
dc.identifier.issn0172-8172-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169583-
dc.description.abstractWe investigated the association of antineutrophil cytoplasmic antibody (ANCA) positivity with lupus nephritis (LN) activity, histological features and prognosis in Korean patients with biopsy-proven LN having the results of both myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3)-ANCA. We retrospectively reviewed the medical records of 91 LN patients having the results of ANCA. We divided patients with LN into the two groups according to the ANCA positivity. We collected clinical and laboratory data at kidney biopsy and histological features such as LN class including class I, II, III, IV-S, IV-G and V, and activity and chronicity index. We evaluated prognosis of LN during the follow-up by death and kidney failure. Twelve of 91 patients (13.2%) had ANCA at kidney biopsy. There were no differences in demographic data, comorbidities, reasons for kidney biopsy and laboratory data at kidney biopsy between patients with and without ANCA. In 12 LN patients with ANCA, Class III was the most frequently observed LN class (41.7%), while in 79 LN patients without ANCA, class IV-G was the most often detected LN class (35.4%). There were no meaningful differences in classes of LN between the two groups. On the other hand, patients with ANCA exhibited the higher median chronicity index than those without (2.5 vs. 1.0, P = 0.028), unlike activity index. ANCA positivity exhibited no association with death or kidney failure during the follow-up. ANCA positivity at kidney biopsy is associated with chronicity index of LN.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfRHEUMATOLOGY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1007/s00296-019-04263-2-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ02625-
dc.identifier.eissn1437-160X-
dc.identifier.pmid30806732-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00296-019-04263-2-
dc.subject.keywordAntineutrophil cytoplasmic antibody-
dc.subject.keywordHistology-
dc.subject.keywordLupus nephritis-
dc.subject.keywordPrognosis-
dc.subject.keywordSystemic lupus erythematosus-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor정승민-
dc.contributor.affiliatedAuthor정승민-
dc.citation.volume39-
dc.citation.number5-
dc.citation.startPage879-
dc.citation.endPage884-
dc.identifier.bibliographicCitationRHEUMATOLOGY INTERNATIONAL, Vol.39(5) : 879-884, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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