0 105

Cited 3 times in

Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors

Authors
 Sumit Barua  ;  Jong Youl Kim  ;  Jae Young Kim  ;  Jae Hwan Kim  ;  Jong Eun Lee 
Citation
 NEUROCHEMICAL RESEARCH, Vol.44(4) : 735-750, 2019 
Journal Title
 NEUROCHEMICAL RESEARCH 
ISSN
 0364-3190 
Issue Date
2019
Keywords
Agmatine ; Ion channels ; Neurodegenerative disease ; Receptor blockade ; Receptors
Abstract
The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is related to abnormal biochemical and electrical signals in the brain cells. As a result, ion channels and receptors that are abundant in the nervous system and control the electrical and biochemical environment of the CNS play a vital role in neurological disease. The N-methyl-D-aspartate receptor, 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptor, kainate receptor, acetylcholine receptor, serotonin receptor, α2-adrenoreceptor, and acid-sensing ion channels are among the major channels and receptors known to be key components of pathophysiological events in the CNS. The primary amine agmatine, a neuromodulator synthesized in the brain by decarboxylation of L-arginine, can regulate ion channel cascades and receptors that are related to the major CNS disorders. In our previous studies, we established that agmatine was related to the regulation of cell differentiation, nitric oxide synthesis, and murine brain endothelial cell migration, relief of chronic pain, cerebral edema, and apoptotic cell death in experimental CNS disorders. In this review, we will focus on the pathophysiological aspects of the neurological disorders regulated by these ion channels and receptors, and their interaction with agmatine in CNS injury.
Full Text
https://link.springer.com/article/10.1007%2Fs11064-018-02712-1
DOI
10.1007/s11064-018-02712-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169536
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse