Cited 12 times in
β-Blockers and 1-Year Postdischarge Mortality for Heart Failure and Reduced Ejection Fraction and Slow Discharge Heart Rate
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.date.accessioned | 2019-05-29T05:17:59Z | - |
dc.date.available | 2019-05-29T05:17:59Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169514 | - |
dc.description.abstract | Background Many hospitalized patients with heart failure and reduced ejection fraction ( HF r EF ) have a slow heart rate at discharge, and the effect of β-blockers may be reduced in those patients. We sought to examine the variable effect of β-blockers on clinical outcomes according to the discharge heart rate of hospitalized HF r EF patients. Methods and Results The KorAHF (Korean Acute Heart Failure) registry consecutively enrolled 5625 patients hospitalized for acute heart failure. In this analysis, we included patients with HF r EF (left ventricular ejection fraction ≤40%). Slow heart rate was defined as <70 beats per minute regardless of the use of β-blockers. The primary outcome was 1-year all-cause postdischarge death according to heart rate. Among 2932 patients with HF r EF , 840 (29%) had a slow heart rate and 56% received β-blockers at discharge. Patients with slow heart rates were older and had lower 1-year mortality than those with high heart rates ( P<0.001). A significant interaction between discharge heart rate and β-blocker use was observed ( P<0.001 for interaction). When stratified, only patients without a β-blocker prescription and with a high heart rate showed higher 1-year mortality. In a Cox-proportional hazards regression analysis, β-blocker prescription at discharge was associated with 24% reduced risk for 1-year mortality in patients with high heart rates (hazard ratio: 0.76; 95% CI, 0.61-0.95) but not in those with slow heart rates (hazard ratio: 1.02; 95% CI, 0.68-1.55). Conclusions Many patients with acute heart failure have slow discharge heart rates, and β-blockers may have a limited effect on HF r EF and slow discharge heart rate. Clinical Trial Registration URL : http://www.clinicaltrial.gov . Unique identifier: NCT 01389843. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | β-Blockers and 1-Year Postdischarge Mortality for Heart Failure and Reduced Ejection Fraction and Slow Discharge Heart Rate | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jin Joo Park | - |
dc.contributor.googleauthor | Hyun-Ah Park | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.contributor.googleauthor | Kye Hun Kim | - |
dc.contributor.googleauthor | Byung-Su Yoo | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Sang Hong Baek | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Jae-Joong Kim | - |
dc.contributor.googleauthor | Myeong-Chan Cho | - |
dc.contributor.googleauthor | Shung Chull Chae | - |
dc.contributor.googleauthor | Byung-Hee Oh | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.identifier.doi | 10.1161/JAHA.118.011121 | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J01774 | - |
dc.identifier.eissn | 2047-9980 | - |
dc.identifier.pmid | 30755071 | - |
dc.subject.keyword | heart failure | - |
dc.subject.keyword | heart rate | - |
dc.subject.keyword | outcome | - |
dc.subject.keyword | β‐blocker | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e011121 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.8(4) : e011121, 2019 | - |
dc.identifier.rimsid | 62657 | - |
dc.type.rims | ART | - |
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