Cited 10 times in
Does the Side Onset of Parkinson's Disease Influence the Time to Develop Levodopa-Induced Dyskinesia?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정석종 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2019-05-29T05:17:21Z | - |
dc.date.available | 2019-05-29T05:17:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1877-7171 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169505 | - |
dc.description.abstract | BACKGROUND: Aberrant plasticity is closely linked to the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). OBJECTIVE: This study investigated whether dominant-side patients with PD exhibit a shorter time to LID development, based on the hypothesis that the dominant hemisphere may have greater plasticity than non-dominant-side patients. METHODS: We analyzed data from 387 right-handed patients with PD who exhibited asymmetric motor deficits and received PD medications for ≥2 years (191 dominant-side and 196 non-dominant-side patients). The influence of side onset on time for LID development was assessed by Kaplan-Meier estimates and time-dependent Cox regression models based on the 5-year time point, after adjusting for age at PD onset, dopamine transporter activity in the posterior putamen, and daily levodopa dose. RESULTS: LID developed in 46 (23.4%) patients with non-dominant-side PD and in 35 (18.1%) patients with dominant-side PD. The Kaplan-Meier analyses revealed that non-dominant-side patients developed LID earlier than dominant-side patients (p = 0.027). The time-dependent Cox regression models showed that the risk of LID within 5 years of treatment was significantly higher in non-dominant-side than in dominant-side patients (hazard ratio 1.954; p = 0.034), whereas the risk after 5 years was similar between groups (p = 0.528). CONCLUSIONS: The present study demonstrated that LID developed earlier in non-dominant-side than in dominant-side patients with PD. These results suggested a greater potential of synaptic plasticity in the dominant hemisphere that may exert a protective role for the development of LID compared to the non-dominant hemisphere. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF PARKINSONS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Does the Side Onset of Parkinson's Disease Influence the Time to Develop Levodopa-Induced Dyskinesia? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Chung, Seok Jong | - |
dc.contributor.googleauthor | Yoo, Han Soo | - |
dc.contributor.googleauthor | Lee, Hye Sun | - |
dc.contributor.googleauthor | Lee, Phil Hyu | - |
dc.contributor.googleauthor | Sohn, Young H. | - |
dc.identifier.doi | 10.3233/JPD-181512 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J01678 | - |
dc.identifier.eissn | 1877-718X | - |
dc.identifier.pmid | 30741690 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd181512 | - |
dc.subject.keyword | Dyskinesia | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | laterality of motor control | - |
dc.subject.keyword | neural plasticity | - |
dc.subject.keyword | risk factors | - |
dc.contributor.alternativeName | Chung, Seok Jong | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 241 | - |
dc.citation.endPage | 247 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PARKINSONS DISEASE, Vol.9(1) : 241-247, 2019 | - |
dc.identifier.rimsid | 62848 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.