0 137

Cited 0 times in

Differential effects of arterial stiffness and fluid overload on blood pressure according to renal function in patients at risk for cardiovascular disease

DC FieldValueLanguage
dc.contributor.author지종현-
dc.contributor.author차민욱-
dc.contributor.author한승혁-
dc.contributor.author박서현-
dc.contributor.author이미솔-
dc.contributor.author안성영-
dc.contributor.author남기헌-
dc.contributor.author지종현-
dc.contributor.author윤해룡-
dc.contributor.author박정탁-
dc.contributor.author김현창-
dc.contributor.author강신욱-
dc.contributor.author박성하-
dc.date.accessioned2019-05-29T05:12:05Z-
dc.date.available2019-05-29T05:12:05Z-
dc.date.issued2019-
dc.identifier.issn0916-9636-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169454-
dc.description.abstractThe pathogenesis of hypertension is multifactorial in patients with chronic kidney disease (CKD). We explored the relative contribution of arterial stiffness and fluid overload to blood pressure (BP) in these patients. We evaluated 1531 patients from a prospective observational cohort study of high-risk patients with cardiovascular disease. BP, arterial stiffness, and volume status expressed as the extracellular water/total body water ratio (ECW/TBW) were measured by 24-h BP monitoring, pulse-wave velocity (PWV), and bioelectrical impedance analysis, respectively. Multiple linear regression analysis showed that both PWV and ECW/TBW of the patients with CKD were significantly associated with 24-h systolic BP (SBP). The areas under the receiver-operating characteristic curve (AUCs) for predicting 24-h SBP ≥130 mm Hg significantly increased after PWV was added to conventional factors regardless of CKD status. However, the AUCs did not increase in the ECW/TBW-based models. When a cut-off 24-h SBP level of 140 mm Hg was used, the predictability of ECW/TBW for elevated BP significantly improved in patients with CKD (0.718 vs. 0.683, P = 0.034) but not in those without. Notably, a significant impact of arterial stiffness on high BP was consistently observed regardless of CKD status. This association was further confirmed by the net reclassification and integrated discriminant improvements, root mean squared error with adjusted R2, and interaction effects. As kidney function declines, fluid overload is significantly associated with high BP. The impact of fluid overload on BP is only observed in more severe hypertension in patients with CKD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfHYPERTENSION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDifferential effects of arterial stiffness and fluid overload on blood pressure according to renal function in patients at risk for cardiovascular disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeohyun Park-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorMisol Lee-
dc.contributor.googleauthorMin-Uk Cha-
dc.contributor.googleauthorSeong Yeong An-
dc.contributor.googleauthorKi Heon Nam-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorHae-Ryong Yun-
dc.contributor.googleauthorHyoungnae Kim-
dc.contributor.googleauthorYoun Kyung Kee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1038/s41440-018-0151-0-
dc.contributor.localIdA03970-
dc.contributor.localIdA05046-
dc.contributor.localIdA05046-
dc.contributor.localIdA04304-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ01017-
dc.identifier.eissn1348-4214-
dc.identifier.pmid30532077-
dc.identifier.urlhttps://www.nature.com/articles/s41440-018-0151-0-
dc.subject.keywordblood pressure-
dc.subject.keywordchronic kidney disease-
dc.subject.keywordfluid overload-
dc.contributor.alternativeNameJhee, Jong Hyun-
dc.contributor.affiliatedAuthor지종현-
dc.contributor.affiliatedAuthor차민욱-
dc.contributor.affiliatedAuthor차민욱-
dc.contributor.affiliatedAuthor한승혁-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume42-
dc.citation.number3-
dc.citation.startPage341-
dc.citation.endPage353-
dc.identifier.bibliographicCitationHYPERTENSION RESEARCH, Vol.42(3) : 341-353, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.