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The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke

DC FieldValueLanguage
dc.contributor.author남효석-
dc.contributor.author허지회-
dc.date.accessioned2019-05-29T05:10:33Z-
dc.date.available2019-05-29T05:10:33Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169444-
dc.description.abstractBackground: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), -39.2 to -3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08-5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinyoul Baik-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorYoung Dae Kim-
dc.identifier.doi10.3389/fneur.2019.00375-
dc.contributor.localIdA01273-
dc.contributor.localIdA04369-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.identifier.pmid31031700-
dc.subject.keywordnon-alcoholic fatty liver disease-
dc.subject.keywordstroke-
dc.subject.keywordstroke functional outcome-
dc.subject.keywordstroke severity-
dc.subject.keywordtransient ischemic attack-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume10-
dc.citation.startPage375-
dc.identifier.bibliographicCitationFRONTIERS IN NEUROLOGY, Vol.10 : 375, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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