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High Receipt of Statins Reduces the Risk of Lung Cancer in Current Smokers With Hypercholesterolemia: The National Health Insurance Service-Health Screening Cohort

Authors
 Yu-Jin Kwon  ;  Na-Young You  ;  Jae-Woo Lee  ;  Joungyoun Kim  ;  Hee-Taik Kang 
Citation
 CLINICAL LUNG CANCER , Vol.20(2) : e177-e185, 2019 
Journal Title
CLINICAL LUNG CANCER
ISSN
 1525-7304 
Issue Date
2019
Keywords
HMG-CoA reductase inhibitors ; Korean men ; Malignancy ; Medication possesion ratio ; Tobacco
Abstract
BACKGROUND: The incidence and mortality of lung cancer have risen steadily with the increasing popularity of tobacco smoking. Observational studies suggest that statins, which are widely used to lower cholesterol, may prevent lung cancer; however, other studies have produced conflicting results. We investigated the effect of statin receipt on lung cancer risk in Korean men according to smoking status.

PATIENTS AND METHODS: We collected data from the 2002-2015 National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS). We included a total of 16,588 men in the final analysis. We classified the participants as having high or low statin receipt or as not receiving statins. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer risk by statin receipt after adjusting for potential confounders.

RESULTS: We identified 363 patients with a new diagnosis of lung cancer from 2005 to 2015. Compared to participants who did not receive statins, high statin receipt resulted in a reduced lung cancer risk (HR = 0.64; 95% CI, 0.47, 0.85) after adjustment for confounders. Among current smokers, the fully adjusted HR for high statin receipt compared to those who did not receive statin therapy was 0.50 (95% CI, 0.32, 0.79).

CONCLUSION: High statin receipt was associated with lower risk of lung cancer in Korean men with hypercholesterolemia, especially current smokers.
Full Text
https://www.sciencedirect.com/science/article/pii/S152573041830305X
DOI
10.1016/j.cllc.2018.11.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169416
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