Cited 8 times in
Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater
DC Field | Value | Language |
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dc.contributor.author | 최혜진 | - |
dc.contributor.author | 장미 | - |
dc.date.accessioned | 2019-05-29T05:06:12Z | - |
dc.date.available | 2019-05-29T05:06:12Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0340-7004 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169400 | - |
dc.description.abstract | Adenocarcinoma of the ampulla of Vater (AOV) is classified into intestinal type (IT) and pancreatobiliary type (PB); however, the immunological properties of these subtypes remain to be characterized. Here, we evaluated the clinical implications of PD-L1 expression and CD8+ T lymphocyte density in adenocarcinomas of the AOV and their potential association with Yes-associated protein (YAP). We analyzed 123 adenocarcinoma-of-the-AOV patients who underwent surgical resection, and tumors were classified into IT or PB type. Tumor or inflammatory cell PD-L1 expression, CD8+ T lymphocyte density in the cancer cell nest (intratumoral) or in the adjacent stroma, and YAP localization and intensity were analyzed using immunohistochemical staining. PB-type tumors showed higher tumoral PD-L1 expression than IT-type tumors, and tumoral PD-L1 expression was associated with a shorter disease-free survival (DFS) [hazard ratio (HR), 1.77; p = 0.045] and overall survival (OS) (HR 1.99; p = 0.030). Intratumoral CD8+ T lymphocyte density was higher in IT type than in PB type and was associated with a favorable DFS (HR 0.47; p = 0.022). The nuclear staining pattern of YAP in tumor cells, compared to non-nuclear staining patterns, was more frequently associated with PB type and increased tumoral PD-L1 expression. Nuclear YAP staining was a significant prognostic factor for OS (HR 2.21; p = 0.022). These results show that the two subtypes of adenocarcinoma of the AOV exhibit significant differences in tumoral PD-L1 expression and intratumoral CD8+ T lymphocyte density, which might contribute to their distinct clinical features. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | CANCER IMMUNOLOGY IMMUNOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/immunology* | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Ampulla of Vater* | - |
dc.subject.MESH | B7-H1 Antigen/analysis | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Common Bile Duct Neoplasms/immunology* | - |
dc.subject.MESH | Common Bile Duct Neoplasms/mortality | - |
dc.subject.MESH | Common Bile Duct Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphocyte Count | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nuclear Proteins/analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Transcription Factors/analysis | - |
dc.title | Distinct immunological properties of the two histological subtypes of adenocarcinoma of the ampulla of Vater | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Min Hwan Kim | - |
dc.contributor.googleauthor | Mi Jang | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.identifier.doi | 10.1007/s00262-018-02293-6 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J00445 | - |
dc.identifier.eissn | 1432-0851 | - |
dc.identifier.pmid | 30604042 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00262-018-02293-6 | - |
dc.subject.keyword | Adenocarcinoma of the ampulla of Vater | - |
dc.subject.keyword | CD8 T lymphocytes | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | PD-L1 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | YAP | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | 최혜진 | - |
dc.citation.volume | 68 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 443 | - |
dc.citation.endPage | 454 | - |
dc.identifier.bibliographicCitation | CANCER IMMUNOLOGY IMMUNOTHERAPY, Vol.68(3) : 443-454, 2019 | - |
dc.identifier.rimsid | 62519 | - |
dc.type.rims | ART | - |
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