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The prevalence and surgical outcomes of Hürthle cell lesions in FNAs of the thyroid: A multi-institutional study in 6 Asian countries
DC Field | Value | Language |
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dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2019-05-29T05:05:56Z | - |
dc.date.available | 2019-05-29T05:05:56Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1934-662X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169396 | - |
dc.description.abstract | BACKGROUND: Hürthle cell-rich nodules (HCNs) encompass non-neoplastic to malignant lesions. There is paucity of literature on the frequency distribution of HCNs among Bethesda categories, histologic follow-up, risk of malignancy (ROM), and risk of neoplasia (RON). The objective of this retrospective, multi-institutional study was to determine the prevalence of the cytologic diagnostic category and surgical outcomes of patients with HCN. METHODS: Nine tertiary health centers representing 6 Asian countries participated. Cases were retrieved from respective databases. The Bethesda System for Reporting Thyroid Cytopathology was used. Cytology results were correlated with surgical diagnoses. RESULTS: Of 42,190 thyroid aspirates retrieved, 760 (1.8%) had a Hürthle cell predominance. Most (61%) were categorized as atypia of undetermined significance/follicular lesion of undetermined significance, Hürthle cell type" (AUS-H); 35% were categorized as follicular neoplasm, Hürthle cell type (FN-H); and 4% were categorized as suspicious for malignancy (SFM). Histologic follow-up was available for 288 aspirates (38%). Most were benign on resection (66%), and the most common histologic diagnosis was Hürthle cell adenoma (28.5%). The ROM for AUS-H, FN-H, and SFM, as calculated on resected nodules, was 32%, 31%, and 71%, respectively; and the RON was 47%, 81%, and 77%, respectively. The 5 institutions that had an AUS-H:HCN ratio below 0.5 diagnosed HCN less frequently as AUS-H than as FN-H. CONCLUSIONS: This is the largest, contemporary, multi-institutional series of HCNs with surgical follow-up. Although there was wide interinstitutional variation in prevalence and surgical outcomes, there was no significant difference in the ROM among institutions. The categories AUS-H and FN-H had a similar ROM for resected nodules. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | CANCER CYTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The prevalence and surgical outcomes of Hürthle cell lesions in FNAs of the thyroid: A multi-institutional study in 6 Asian countries | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Shipra Agarwal | - |
dc.contributor.googleauthor | Andrey Bychkov | - |
dc.contributor.googleauthor | Chan Kwon Jung | - |
dc.contributor.googleauthor | Mitsuyoshi Hirokawa | - |
dc.contributor.googleauthor | Chiung‐Ru Lai | - |
dc.contributor.googleauthor | SoonWon Hong | - |
dc.contributor.googleauthor | Hyeong Ju Kwon | - |
dc.contributor.googleauthor | Samreung Rangdaeng | - |
dc.contributor.googleauthor | Zhiyan Liu | - |
dc.contributor.googleauthor | Peng Su | - |
dc.contributor.googleauthor | Kennichi Kakudo | - |
dc.contributor.googleauthor | Deepali Jain | - |
dc.identifier.doi | 10.1002/cncy.22101 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00438 | - |
dc.identifier.eissn | 1934-6638 | - |
dc.identifier.pmid | 30668897 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/cncy.22101 | - |
dc.subject.keyword | Hürthle cell lesion | - |
dc.subject.keyword | Hürthle cell neoplasm | - |
dc.subject.keyword | Hürthle cell type | - |
dc.subject.keyword | atypia of undetermined significance/follicular lesion of undetermined significance | - |
dc.subject.keyword | fine-needle aspiration (FNA) | - |
dc.subject.keyword | follicular neoplasm | - |
dc.subject.keyword | risk of malignancy (ROM) | - |
dc.subject.keyword | risk of neoplasia (RON) | - |
dc.subject.keyword | the Bethesda System for Reporting Thyroid Cytopathology | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | 홍순원 | - |
dc.citation.volume | 127 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 191 | - |
dc.identifier.bibliographicCitation | CANCER CYTOPATHOLOGY, Vol.127(3) : 181-191, 2019 | - |
dc.identifier.rimsid | 62529 | - |
dc.type.rims | ART | - |
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