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Hypothalamic inflammation and obesity: a mechanistic review

Authors
 Jichang Seong  ;  Jung Yun Kang  ;  Ji Su Sun  ;  Ki Woo Kim 
Citation
 ARCHIVES OF PHARMACAL RESEARCH, Vol.42(5) : 383-392, 2019 
Journal Title
 ARCHIVES OF PHARMACAL RESEARCH 
ISSN
 0253-6269 
Issue Date
2019
Keywords
Astrocyte ; Hypothalamus ; Inflammation ; Microglia ; Obesity
Abstract
Obesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Several underlying mechanisms have been proposed, yet compelling evidences require further elucidations. This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.
Full Text
https://link.springer.com/article/10.1007%2Fs12272-019-01138-9
DOI
10.1007/s12272-019-01138-9
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Woo(김기우) ORCID logo https://orcid.org/0000-0002-7790-1515
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169369
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