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Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography

 Yun Ha Lee  ;  Hyoung Won Bae  ;  Sang Jin Seo  ;  Sang Yeop Lee  ;  Seok Ho Beon  ;  Sungyong Kang  ;  Chan Yun Kim 
 BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.100(8) : 1035-1040, 2016 
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Issue Date
Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Epiretinal Membrane/diagnosis* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Optic Disk/pathology* ; Retinal Ganglion Cells/pathology* ; Retrospective Studies ; Severity of Illness Index ; Tomography, Optical Coherence/methods* ; Visual Acuity
BACKGROUND/AIMS: To investigate the effect of epiretinal membrane (ERM) on peripapillary retinal nerve fibre layer (RNFL) thickness measurements using spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering).

METHODS: A total of 134 patients with idiopathic ERM and 63 healthy controls were included in this observational comparative study. We categorised ERMs into three severity grades, based on retinal appearance in macular scans. All eyes with ERM were classified into two groups; those involving the peripapillary scan area (ERM+pp, n=68 eyes) and not involving the peripapillary scan area (ERM-pp, n=66 eyes) using the macular disc scan. Peripapillary RNFL thickness was compared between related subgroups as (ERM+pp) or (ERM-pp) group.

RESULTS: Temporal peripapillary RNFL thickness was significantly greater in the ERM+pp group (109.44±22.91 μm), followed by the ERM-pp (82.60±11.77 μm, p<0.001) and control (75.42±10.49 μm, p<0.001) groups. Temporal peripapillary RNFL thickness significantly increased with ERM grade in the ERM+pp and ERM-pp groups (both p<0.001). The peripapillary RNFL thickness was overestimated (exceeded 99th percentile) in the temporal sector in 49 eyes (72.1%) in the ERM+pp group and in 5 eyes (7.6%) in the ERM-pp group.

CONCLUSIONS: Temporal and global peripapillary RNFL thickness is significantly higher in eyes with ERM, especially when the ERM extends into the peripapillary area. However, some eyes with an ERM that does not involve the peripapillary scan area still show peripapillary RNFL thickening. Measured peripapillary RNFL thickness was significantly and positively correlated with ERM severity.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
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