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Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial

 A-Ra Cho  ;  Ju-Yeon Moon  ;  Sue Kim  ;  Ki-Yong An  ;  Minsuk Oh  ;  Justin Y. Jeon  ;  Dong-Hyuk Jung  ;  Man Ho Choi  ;  Ji-Won Lee 
 Metabolism: Clinical and Experimental, Vol.93 : 52-60, 2019 
Journal Title
 Metabolism: Clinical and Experimental 
Issue Date
Alternative day fasting ; Cholesterol metabolism ; Exercise ; Obesity ; Serum sterols
BACKGROUND AND PURPOSE: The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis. METHODS: We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography-mass spectrometry. RESULTS: After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p < 0.05 by analysis of covariance [ANCOVA]). We found no differences in plant sterols, which are markers of cholesterol absorption. In the exercise group, desmosterol, cholesteryl esters, and oxysterols decreased significantly. Furthermore, only changes in physical activity levels negatively correlated with changes in the metabolic ratios of desmosterol and 7-dehydrocholesterol to cholesterol, which reflect cholesterol biosynthesis (r = -0.411; p = 0.030, and r = -0.540; p = 0.003, respectively). CONCLUSION: These findings suggest that exercise with or without ADF improves cholesterol metabolism as measured by serum sterol signatures, and increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sue(김수)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
Cho, A Ra(조아라) ORCID logo https://orcid.org/0000-0002-3645-2282
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