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Time-Phasic Development of Nitrate Tolerance According to the Hemodynamic Responses and the Expression of Phosphodiesterase 1A1
DC Field | Value | Language |
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dc.contributor.author | 최의영 | - |
dc.contributor.author | 김동수 | - |
dc.contributor.author | 홍범기 | - |
dc.contributor.author | 권혁문 | - |
dc.contributor.author | 윤영원 | - |
dc.contributor.author | 이윤우 | - |
dc.date.accessioned | 2019-04-22T02:41:31Z | - |
dc.date.available | 2019-04-22T02:41:31Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167922 | - |
dc.description.abstract | Background and Objectives:Time-phasic development of nitrate tolerance in cardiovascular diseases is very important because it can contribute to the advent of blunted vasodilation or rebound ischemia even during continuous NTG treatment. In such a condition, we should change the therapeutic regimen of nitrate treatment to prevent the worsening of symptoms. Materials and Methods:We created a nitrate-tolerant rat model using an osmotic minipump, and we examined the hemodynamic response to bolus NTG infusion in vivo. We checked the phosphodiesterase (PDE)1A1 mRNA and protein level by relative quantitative RT-PCR and western blot analysis. We used 8-cpt-cGMP for investigating the development of a time-phasic nitrate tolerance mechanism after nitrate infusion. Results:NTG-treated rats revealed a significant decrease in NTG-induced MAP drop (nitrate tolerance) from 1-day and this continued to the third day. The mRNA and protein levels of PDE1A1 similarly increased during these periods. Conclusion:This study revealed the development of time-phasic nitrate tolerance from the the aspects of in vivo hemodynamic responses and PDE 1A1 gene expression, and our work supports the need for further investigation to come up with a different therapeutic strategy and new drugs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Time-Phasic Development of Nitrate Tolerance According to the Hemodynamic Responses and the Expression of Phosphodiesterase 1A1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Dongsoo Kim | - |
dc.contributor.googleauthor | Bum Kee Hong | - |
dc.contributor.googleauthor | Eui-Young Choi | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Dong-Yun Kim | - |
dc.contributor.googleauthor | Sung Woo Kwon | - |
dc.contributor.googleauthor | Sung Ju Lee | - |
dc.contributor.googleauthor | Jong Kwan Park | - |
dc.contributor.googleauthor | Young Won Yoon | - |
dc.contributor.googleauthor | Hyun-Seung Kim | - |
dc.contributor.localId | A04165 | - |
dc.contributor.localId | A00404 | - |
dc.contributor.localId | A04394 | - |
dc.contributor.localId | A00260 | - |
dc.contributor.localId | A02580 | - |
dc.contributor.localId | A03022 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Nitrates;Hemodynamic phenomena;Phosphodiesterases;Aorta | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | 최의영 | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.contributor.affiliatedAuthor | 홍범기 | - |
dc.contributor.affiliatedAuthor | 권혁문 | - |
dc.contributor.affiliatedAuthor | 윤영원 | - |
dc.contributor.affiliatedAuthor | 이윤우 | - |
dc.citation.volume | 35 | - |
dc.citation.startPage | 94 | - |
dc.citation.endPage | 99 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.35 : 94-99, 2005 | - |
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