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Monopolar vs. bipolar transurethral resection for non-muscle invasive bladder carcinoma: A post-hoc analysis from a randomized controlled trial

Authors
 Esmee I.M.L. Liem  ;  Michael McCormack  ;  Eddie S.Y. Chan  ;  Yoshiyuki Matsui  ;  Petrisor Geavlete  ;  Young D. Choi  ;  Theo M. de Reijke  ;  Yasser Farahat  ;  Brant A. Inman  ;  Jean J.M.C.H. de la Rosette  ;  Seiji Naito 
Citation
 UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol.36(7) : 338.e1-338.e11, 2018 
Journal Title
 UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 
ISSN
 1078-1439 
Issue Date
2018
MeSH
Aged ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery* ; Postoperative Complications* ; Prognosis ; Survival Rate ; Urinary Bladder/pathology ; Urinary Bladder/surgery* ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery* ; Urologic Surgical Procedures/methods*
Keywords
Bipolar ; Monopolar ; Non–muscle invasive bladder cancer ; Transurethral resection bladder tumor (TURB) ; Urothelial carcinoma
Abstract
PURPOSE: Traditionally, transurethral resection of bladder tumors (TURB) is performed using monopolar technique. Bipolar resection has been postulated to reduce complications. In this study we compare safety and efficacy between monopolar TURB (mTURB) and bipolar TURB (bTURB) for patients with primary non-muscle invasive bladder cancer (NMIBC). MATERIALS AND METHODS: Data were obtained from an international multicenter randomized clinical trial that compared the use of white light cystoscopy with narrow band imaging-assisted TURB using the Olympus system between 2010 and 2014. Main outcomes of interest were operative time, perioperative, and postoperative complications, and 12-month recurrence-free survival. RESULTS: In total, 716 patients were treated for primary NMIBC with mTURB (310 patients) or bTURB (406 patients). The use of white light cystoscopy or narrow band imaging was equally distributed between the 2 resection techniques. Multilevel logistic and linear regression corrected for possible confounders showed no significant difference between mTURB and bTURB for postoperative complications (OR = 1.76, P = 0.180), postoperative bleeding (OR = 1.27, P = 0.722), and the combination of intra + postoperative bleeding (OR = 1.992, P = 0.108). Additionally, no significant difference was found between mTURB and bTURB concerning operative time (1.05min. longer for bTURB, P = 0.536), intraoperative bleeding requiring intervention (OR:1.38, P=0.809), incidence of obturator reflex (OR = 0.93, P = 0.854), and bladder perforation (OR = 3.05, P = 0.195). In total, 185 patients (25.8%) developed a recurrence (mTURB = 88, bTURB = 97). Recurrence-free survival at 12 months in the mTURB and bTURB group was 70% and 74% (P = 0.410), respectively. CONCLUSION: Based on these results, bTURB is as safe and effective as mTURB in treatment of primary NMIBC. bTURB seems to have no evident advantages over mTURB with respect to operation time, perioperative and postoperative complication rates, and recurrence rates at 12 months.
Full Text
https://www.sciencedirect.com/science/article/pii/S1078143918300978
DOI
10.1016/j.urolonc.2018.03.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167639
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