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Evaluation of 18F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma

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dc.contributor.author왕지영-
dc.contributor.author윤미진-
dc.contributor.author조응혁-
dc.contributor.author차종태-
dc.contributor.author왕지영-
dc.date.accessioned2019-03-15T02:36:06Z-
dc.date.available2019-03-15T02:36:06Z-
dc.date.issued2018-
dc.identifier.issn1869-3474-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167610-
dc.description.abstractPurpose: The purpose of this study was to investigate the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters in the detection of regional lymph node (LN) metastasis in patients with cutaneous melanoma. Methods: We evaluated patients with cutaneous melanoma who underwent FDG PET/CT for initial staging or recurrence evaluation. A total of 103 patients were enrolled, and 165 LNs were evaluated. LNs that were confirmed pathologically or by follow-up imaging were included in this study. PET parameters, including maximum standardized uptake value (SUVmax), total lesion glycolysis and tumour-to-liver ratio, were used to determine the presence of metastases, and the results were compared with CT-determined LN metastasis. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values of the FDG PET parameters. Results: A total of 93 LNs were malignant, and 84 LNs were smaller than 10 mm. In all 165 LNs, an SUVmax of >2.51 showed a sensitivity of 73.1%, a specificity of 88.9%, and an accuracy of 80.0% in detecting metastatic LNs. CT showed a higher specificity (87.3%) and lower accuracy (65.5%). For non-enlarged regional LNs (<10 mm), an SUVmax cut-off value of 1.4 showed the highest negative predictive value (81.3%). For enlarged LNs (≥10 mm), an SUVmax cut-off value of 2.4 showed the highest sensitivity (90.7%) and accuracy (88.9%) in detecting metastatic LNs. Conclusions: In patients with cutaneous melanoma, an SUVmax of >2.4 showed a high sensitivity (91%) and accuracy (89%) in detecting metastasis in LNs ≥1 cm, and LNs <1 cm with an SUVmax <1.4 were likely to be benign.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisherKorean Society of Nuclear Medicine-
dc.relation.isPartOfNUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEvaluation of 18F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorJongtae Cha-
dc.contributor.googleauthorSoyoung Kim-
dc.contributor.googleauthorJiyoung Wang-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorArthur Cho-
dc.identifier.doi10.1007/s13139-017-0495-4-
dc.contributor.localIdA05697-
dc.contributor.localIdA02550-
dc.contributor.localIdA03887-
dc.contributor.localIdA04801-
dc.relation.journalcodeJ02382-
dc.identifier.eissn1869-3482-
dc.identifier.pmid29391911-
dc.subject.keywordCutaneous melanoma-
dc.subject.keywordFDG PET/CT-
dc.subject.keywordLymph node metastasis-
dc.subject.keywordSensitivity-
dc.contributor.alternativeNameWang, Jiyoung-
dc.contributor.affiliatedAuthor왕지영-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor조응혁-
dc.contributor.affiliatedAuthor차종태-
dc.citation.volume52-
dc.citation.number1-
dc.citation.startPage39-
dc.citation.endPage45-
dc.identifier.bibliographicCitationNUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.52(1) : 39-45, 2018-
dc.identifier.rimsid46367-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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