Cited 4 times in
A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이혜원 | - |
dc.date.accessioned | 2019-03-15T02:35:41Z | - |
dc.date.available | 2019-03-15T02:35:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167608 | - |
dc.description.abstract | Liver cirrhotic patients suffer from a seemingly unpredictable risk of hepatocellular carcinoma (HCC). Here, an HCC risk score R (0 ≦ R ≦ 1) was derived from commonly tested haematological and biochemical parameters. In the score-derivation Taiwanese cohort (144 cirrhosis versus 48 HCC-remission patients), the score had an area-under-the-curve (AUC) of 0.70 (95% confidence interval [CI], 0.61-0.78, P < 0.001). When validated in a Korean cohort (78 cirrhosis versus 23 HCC-remission patients), the AUC was 0.68 (CI, 0.56-0.80, P = 0.009). In a multicentre prospective cohort (478 cirrhotic patients prospectively followed for HCC occurrence), the hazard ratio with respect to R was 2.344 (CI = 1.183-4.646, P = 0.015). The cumulative incidences of HCC at two years after patient enrolment were 9.6% and 1.7% for the high-risk (R ≧ 0.5) and low-risk (R < 0.5) groups, respectively (P < 0.001). At the end of the study, the incidences were 10.9% and 5.0%, respectively (P = 0.012). The majority of HCCs (23/26) in the high-risk group emerged within the first two years of follow-up. In conclusion, an HCC risk score was developed for cirrhotic patients that effectively predicted HCC in a prospective cohort study. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A novel risk score for hepatocellular carcinoma in Asian cirrhotic patients: a multicentre prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kung-Hao Liang | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Hye Wong Lee | - |
dc.contributor.googleauthor | Ya-Hui Huang | - |
dc.contributor.googleauthor | Rong-Nan Chien | - |
dc.contributor.googleauthor | Tsung-Hui Hu | - |
dc.contributor.googleauthor | Kwang-Huei Lin | - |
dc.contributor.googleauthor | Christopher Sung-Huan Yeh | - |
dc.contributor.googleauthor | Chao-Wei Hsu | - |
dc.contributor.googleauthor | Chih-Lang Lin | - |
dc.contributor.googleauthor | Tai-Long Pan | - |
dc.contributor.googleauthor | Po-Yuan Ke | - |
dc.contributor.googleauthor | Ming-Ling Chang | - |
dc.contributor.googleauthor | Chau-Ting Yeh | - |
dc.identifier.doi | 10.1038/s41598-018-26992-3 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03318 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29872158 | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 8608 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.8(1) : 8608, 2018 | - |
dc.identifier.rimsid | 46365 | - |
dc.type.rims | ART | - |
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