Cited 17 times in
The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2019-03-15T02:35:35Z | - |
dc.date.available | 2019-03-15T02:35:35Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167607 | - |
dc.description.abstract | BACKGROUND: Interferon (IFN)-based regimens cause significant impairment of health-related quality of life (HRQL). Hepatitis C virus (HCV) cure with IFN-free regimens improves HRQL. The effect of these regimens on HRQL in East Asian HCV patients is unclear due to lack of published evidence. AIM: To assess HRQL in East Asian HCV patients treated with an IFN-free regimen with sofosbuvir+ribavirin. METHODS: Patients completed Short Form-36 (SF-36) before, during and after treatment. RESULTS: 686 subjects were included (China: 56.7%; S. Korea: 18.8%; Taiwan: 12.7%; genotype 2: 40.8%; genotype 1: 29.6%; genotype 3: 18.4%; genotype 6: 11.2%; cirrhosis: 13.4%; treatment-naïve: 66.5%). Patients received either pegylated-IFN, sofosbuvir, and ribavirin (IFN+SOF+RBV) for 12 weeks (n = 155, genotypes 1 and 6) or SOF+RBV for 12-24 weeks (n = 531, all genotypes). The SVR-12 rates were 95.5% and 96.0%; respectively (P = .76). Baseline HRQL scores were similar between treatment groups (all P > .05). By the end of treatment, the IFN-treated group experienced significant declines in most HRQL scores (on average, by up to -13.3 points on a 0-100 scale from the baseline level, P < .02) while subjects on SOF/RBV had milder impairments (up to -5.4 points). Achieving SVR-12 was associated with HRQL improvement regardless of regimen (up to +2.9 points, P < .05). The use of IFN-free treatment was a consistent independent predictor of higher HRQL scores during treatment (β: +2.1 to +10.7 points, P < .02). CONCLUSIONS: East Asian HCV patients treated with an IFN-free regimen had better on-treatment HRQL scores. These data should inform policymakers about the comprehensive benefits of IFN-free regimens in East Asian patients with HCV. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Zobair M. Younossi | - |
dc.contributor.googleauthor | Maria Stepanova | - |
dc.contributor.googleauthor | Linda Henry | - |
dc.contributor.googleauthor | Kwang‐Hyub Han | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Young‐Suk Lim | - |
dc.contributor.googleauthor | Wan‐Long Chuang | - |
dc.contributor.googleauthor | Jia‐Horng Kao | - |
dc.contributor.googleauthor | Nguyen Kinh | - |
dc.contributor.googleauthor | Ching Lung Lai | - |
dc.contributor.googleauthor | Man‐Fung Yuen | - |
dc.contributor.googleauthor | Henry Lik‐Yuen Chan | - |
dc.contributor.googleauthor | Wei Lai | - |
dc.identifier.doi | 10.1111/liv.13650 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 29197140 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/liv.13650 | - |
dc.subject.keyword | direct-acting antivirals | - |
dc.subject.keyword | mental health | - |
dc.subject.keyword | physical functioning | - |
dc.subject.keyword | sofosbuvir | - |
dc.subject.keyword | vitality | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 한광협 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1179 | - |
dc.citation.endPage | 1187 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.38(7) : 1179-1187, 2018 | - |
dc.identifier.rimsid | 46364 | - |
dc.type.rims | ART | - |
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