Cited 15 times in
Sofosbuvir and ledipasvir are associated with high sustained virologic response and improvement of health-related quality of life in East Asian patients with hepatitis C virus infection
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2019-03-15T02:35:32Z | - |
dc.date.available | 2019-03-15T02:35:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167606 | - |
dc.description.abstract | Although HCV infection is highly prevalent in East Asia, these patients have been underrepresented in HRQL studies. Here, we assess HRQL in East Asian HCV patients treated with different anti-HCV regimens. Patients completed Short Form-36 (SF-36) before, during and after treatment. A total of 989 HCV patients were enrolled in two phase 3 clinical trials [China: 60.2%, South Korea: 22.4%, Taiwan: 17.4%; genotype 1: 55.3%, treatment-naïve: 57.5%; cirrhosis: 14.0%]. Patients received pegylated interferon, sofosbuvir and ribavirin (Peg-IFN + SOF + RBV; n = 130, genotypes 1, 6) or SOF + RBV (n = 475, all genotypes) or SOF and ledipasvir (LDV/SOF; n = 384, genotype 1). The SVR-12 rates were 94.6%, 96.2% and 99.2%, respectively (P = 0.005). During treatment, Peg-IFN + SOF + RBV-treated group experienced significant declines in most HRQL scores (by the end of treatment, mean decline up to -12.0 points, all P < 0.05). Patients on SOF + RBV had milder HRQL impairment (up to -5.8 points, P < 0.05 for 5 of 8 HRQL domains). In contrast, patients receiving IFN- and RBV-free regimen with LDV/SOF had their HRQL scores improve (mean up to +4.3 points, P < 0.0001 for 3 of 8 scales). In multivariate analysis, receiving Peg-IFN + SOF + RBV was consistently independently associated with HRQL impairment during treatment (β: -10.3 to -16.4) and after achieving SVR-12 (β: -4.4 to -9.1) (all P < 0.01). The results were reproduced in a subgroup of patients enrolled in China. We conclude that in East Asian patients with HCV, HRQL improved from baseline after treatment with LDV/SOF but not with Peg-IFN + RBV-containing or Peg-IFN-free RBV-containing regimens. The HRQL impairment associated with the use of Peg-IFN persists even after achieving sustained virologic clearance. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF VIRAL HEPATITIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sofosbuvir and ledipasvir are associated with high sustained virologic response and improvement of health-related quality of life in East Asian patients with hepatitis C virus infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Zobair M. Younossi | - |
dc.contributor.googleauthor | Maria Stepanova | - |
dc.contributor.googleauthor | Linda Henry | - |
dc.contributor.googleauthor | Kwang‐Hyub Han | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Young‐Suk Lim | - |
dc.contributor.googleauthor | Wan‐Long Chuang | - |
dc.contributor.googleauthor | Jia‐Horng Kao | - |
dc.contributor.googleauthor | Kinh V. Nguyen | - |
dc.contributor.googleauthor | Ching Lung Lai | - |
dc.contributor.googleauthor | Henry Lik‐Yuen Chan | - |
dc.contributor.googleauthor | Lai Wei | - |
dc.identifier.doi | 10.1111/jvh.12965 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J01928 | - |
dc.identifier.eissn | 1365-2893 | - |
dc.identifier.pmid | 29974665 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/jvh.12965 | - |
dc.subject.keyword | direct-acting antivirals | - |
dc.subject.keyword | health-related quality of life | - |
dc.subject.keyword | mental health | - |
dc.subject.keyword | physical functioning | - |
dc.subject.keyword | vitality | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 한광협 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1429 | - |
dc.citation.endPage | 1437 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIRAL HEPATITIS, Vol.25(12) : 1429-1437, 2018 | - |
dc.identifier.rimsid | 46363 | - |
dc.type.rims | ART | - |
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