Cited 43 times in
Hepatitis B Surface Antigen Loss with Tenofovir Disoproxil Fumarate Plus Peginterferon Alfa-2a: Week 120 Analysis
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.date.accessioned | 2019-03-15T02:35:23Z | - |
dc.date.available | 2019-03-15T02:35:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167603 | - |
dc.description.abstract | BACKGROUND AND AIMS: Hepatitis B surface antigen (HBsAg) loss is the ideal clinical endpoint but is achieved rarely during oral antiviral treatment. A current unmet need in CHB management is achievement of HBsAg loss with a finite course of oral antiviral therapy, thereby allowing discontinuation of treatment. Significantly higher rates of HBsAg loss at 72 weeks post-treatment have been demonstrated when tenofovir disoproxil fumarate (TDF) was combined with pegylated interferon (PEG-IFN) for 48 weeks compared with either monotherapy. This analysis provides follow-up data at week 120. METHODS: In an open-label, active-controlled study, 740 patients with chronic hepatitis B were randomly assigned to receive TDF plus PEG-IFN for 48 weeks (group A), TDF plus PEG-IFN for 16 weeks followed by TDF for 32 weeks (group B), TDF for 120 weeks (group C), or PEG-IFN for 48 weeks (group D). Efficacy and safety at week 120 were assessed. RESULTS: Rates of HBsAg loss at week 120 were significantly higher in group A (10.4%) than in group B (3.5%), group C (0%), and group D (3.5%). Rates of HBsAg loss and HBsAg seroconversion in group A were significantly higher than rates in group C (P < 0.001 for both) or group D (HBsAg loss: P = 0.002; HBsAg seroconversion: P < 0.001). CONCLUSIONS: The results of this analysis confirm the results from earlier time points which demonstrate the increased rate of HBsAg loss in patients treated with a finite course of PEG-IFN plus TDF compared with the rates in patients receiving either monotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Springer Science + Business Media | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Hepatitis B Surface Antigen Loss with Tenofovir Disoproxil Fumarate Plus Peginterferon Alfa-2a: Week 120 Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Patrick Marcellin | - |
dc.contributor.googleauthor | Xiaoli Ma | - |
dc.contributor.googleauthor | Florin A. Caruntu | - |
dc.contributor.googleauthor | Won Young Tak | - |
dc.contributor.googleauthor | Magdy Elkhashab | - |
dc.contributor.googleauthor | Wan-Long Chuang | - |
dc.contributor.googleauthor | Fehmi Tabak | - |
dc.contributor.googleauthor | Rajiv Mehta | - |
dc.contributor.googleauthor | Jörg Petersen | - |
dc.contributor.googleauthor | William Guyer | - |
dc.contributor.googleauthor | Belinda Jump | - |
dc.contributor.googleauthor | Alain Chan | - |
dc.contributor.googleauthor | Mani Subramanian | - |
dc.contributor.googleauthor | Gerald Crans | - |
dc.contributor.googleauthor | Scott Fung | - |
dc.contributor.googleauthor | Maria Buti | - |
dc.contributor.googleauthor | Giovanni B. Gaeta | - |
dc.contributor.googleauthor | Aric J. Hui | - |
dc.contributor.googleauthor | George Papatheodoridis | - |
dc.contributor.googleauthor | Robert Flisiak | - |
dc.contributor.googleauthor | Henry L. Y. Chan | - |
dc.identifier.doi | 10.1007/s10620-018-5251-9 | - |
dc.contributor.localId | A02226 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 30136045 | - |
dc.subject.keyword | Chronic hepatitis B | - |
dc.subject.keyword | HBsAg loss | - |
dc.subject.keyword | HBsAg seroconversion | - |
dc.subject.keyword | Virological response | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3487 | - |
dc.citation.endPage | 3497 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.63(12) : 3487-3497, 2018 | - |
dc.identifier.rimsid | 46360 | - |
dc.type.rims | ART | - |
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