Cited 24 times in
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey
DC Field | Value | Language |
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dc.contributor.author | 박은철 | - |
dc.contributor.author | 이산 | - |
dc.contributor.author | 장성인 | - |
dc.date.accessioned | 2019-03-15T02:33:02Z | - |
dc.date.available | 2019-03-15T02:33:02Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167571 | - |
dc.description.abstract | Elevated levels of circulating high-sensitivity C-reactive protein (hs-CRP) have been observed in depression, with the body mass index (BMI) being a major mediator of this association. However, the sex difference in the association between hs-CRP and depression remains unclear. This study aimed to investigate the sex difference in the association between hs-CRP and depression. Data from the 2016 Korea National Health and Nutritional Examination Survey were used for our study. High hs-CRP was defined as >3.0 mg/L, while depression was determined using a cut-off score of 10 in the Patient Health Questionnaire-9. The study population comprised 5,483 Korean adults. Men with high hs-CRP levels showed statistically higher prevalence of depression than those with low hs-CRP levels (8.90% vs. 3.65%, P < 0.0001). The high hs-CRP group was 1.86 times more likely to have depression after adjusting for BMI and other covariates in men (adjusted odds ratio: 1.86; 95% confidence interval: 1.07-3.25; P = 0.029). Meanwhile, no statistically significant association between hs-CRP and depression was found among women. Depression was considerably associated with hs-CRP only in men, indicating a biological difference between men and women that can independently modify the relationship between hs-CRP and depression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | San Lee | - |
dc.contributor.googleauthor | Sarah Soyeon Oh | - |
dc.contributor.googleauthor | Sung-In Jang | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.identifier.doi | 10.1038/s41598-018-36402-3 | - |
dc.contributor.localId | A01618 | - |
dc.contributor.localId | A05001 | - |
dc.contributor.localId | A03439 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 30760746 | - |
dc.contributor.alternativeName | Park, Eun-Chul | - |
dc.contributor.affiliatedAuthor | 박은철 | - |
dc.contributor.affiliatedAuthor | 이산 | - |
dc.contributor.affiliatedAuthor | 장성인 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1918 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : 1918, 2019 | - |
dc.identifier.rimsid | 47017 | - |
dc.type.rims | ART | - |
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