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Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey

DC Field Value Language
dc.contributor.author박은철-
dc.contributor.author이산-
dc.contributor.author장성인-
dc.date.accessioned2019-03-15T02:33:02Z-
dc.date.available2019-03-15T02:33:02Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167571-
dc.description.abstractElevated levels of circulating high-sensitivity C-reactive protein (hs-CRP) have been observed in depression, with the body mass index (BMI) being a major mediator of this association. However, the sex difference in the association between hs-CRP and depression remains unclear. This study aimed to investigate the sex difference in the association between hs-CRP and depression. Data from the 2016 Korea National Health and Nutritional Examination Survey were used for our study. High hs-CRP was defined as >3.0 mg/L, while depression was determined using a cut-off score of 10 in the Patient Health Questionnaire-9. The study population comprised 5,483 Korean adults. Men with high hs-CRP levels showed statistically higher prevalence of depression than those with low hs-CRP levels (8.90% vs. 3.65%, P < 0.0001). The high hs-CRP group was 1.86 times more likely to have depression after adjusting for BMI and other covariates in men (adjusted odds ratio: 1.86; 95% confidence interval: 1.07-3.25; P = 0.029). Meanwhile, no statistically significant association between hs-CRP and depression was found among women. Depression was considerably associated with hs-CRP only in men, indicating a biological difference between men and women that can independently modify the relationship between hs-CRP and depression.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorSan Lee-
dc.contributor.googleauthorSarah Soyeon Oh-
dc.contributor.googleauthorSung-In Jang-
dc.contributor.googleauthorEun-Cheol Park-
dc.identifier.doi10.1038/s41598-018-36402-3-
dc.contributor.localIdA01618-
dc.contributor.localIdA05001-
dc.contributor.localIdA03439-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid30760746-
dc.contributor.alternativeNamePark, Eun-Chul-
dc.contributor.affiliatedAuthor박은철-
dc.contributor.affiliatedAuthor이산-
dc.contributor.affiliatedAuthor장성인-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage1918-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.9(1) : 1918, 2019-
dc.identifier.rimsid47017-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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